Evidence map›Paper›PMID 42243149›Full record

ArticleNature communications2026

Bypassing the VTA: Thalamic modulation of striatal dopamine prioritizes safety.

Rachel E Clarke, James M Otis

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rachel E ClarkeDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA.ORCID http://orcid.org/0000-0002-3690-2028
James M OtisDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, USA. otis@musc.edu.ORCID http://orcid.org/0000-0003-0953-9283

Funding

Multiplexed dissection of neuronal ensembles in circuits that underlie the facilitation and disinhibition of opioid and alcohol seekingR01DA062041 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Stefano Berto, Christopher W Cowan · 2025 to 2026
$2.0M
Thalamostriatal Circuitry in Opioid SeekingR01DA054271 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI James M Otis · 2022 to 2026
$1.7M
BLRD VA I01 BX006179NIDA NIH HHS R01 DA054271NIDA NIH HHS R01 DA062041U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01-DA054271U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01-DA062041U.S. Department of Veterans Affairs (Department of Veterans Affairs) I01-BX006179
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID42243149
PMCPMC13237103

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.