Evidence map›Paper›PMID 42243126›Full record

ArticleNature communications2026

Myosin light chain proteins cooperatively promote sarcomere growth in fast-twitch muscle.

Tayo E Adekeye, Troy E Hupper, Teresa E Easterbrooks, Emily M Teets, Emily A Tomak, Sadie L Waterman, Kailee A Sprague, Angelina White, Maddison L Coffin, Daniel K Tanaka and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Tayo E AdekeyeSchool of Biology and Ecology, The University of Maine, Orono, ME, USA.ORCID http://orcid.org/0009-0000-9764-9030
Troy E HupperSchool of Biology and Ecology, The University of Maine, Orono, ME, USA.
Teresa E EasterbrooksSchool of Biology and Ecology, The University of Maine, Orono, ME, USA.
Emily M TeetsDepartment of Molecular Genetics, The Ohio State University, Columbus, OH, USA.
Emily A TomakSchool of Biology and Ecology, The University of Maine, Orono, ME, USA.
Sadie L WatermanSchool of Biology and Ecology, The University of Maine, Orono, ME, USA.
Kailee A SpragueSchool of Biology and Ecology, The University of Maine, Orono, ME, USA.
Angelina WhiteSchool of Biology and Ecology, The University of Maine, Orono, ME, USA.
Maddison L CoffinSchool of Biology and Ecology, The University of Maine, Orono, ME, USA.
Daniel K TanakaSchool of Biology and Ecology, The University of Maine, Orono, ME, USA.ORCID http://orcid.org/0009-0004-6637-1119
Sabrina M VargaSchool of Biology and Ecology, The University of Maine, Orono, ME, USA.
Mason T SoaresSchool of Biology and Ecology, The University of Maine, Orono, ME, USA.
Sarah J ShepherdDepartment of Molecular Genetics, The Ohio State University, Columbus, OH, USA.
Jared D AustinSchool of Biology and Ecology, The University of Maine, Orono, ME, USA.
Dmitrii KrivorotkoSchool of Biology and Ecology, The University of Maine, Orono, ME, USA.
Emma S PerryCore Electron Microscopy Laboratory, The University of Maine, Orono, ME, USA.
Sharon L AmacherDepartment of Molecular Genetics, The Ohio State University, Columbus, OH, USA.
Joshua B KelleyMolecular and Biomedical Sciences, The University of Maine, Orono, ME, USA.ORCID http://orcid.org/0000-0002-5700-1173
Jared C TalbotSchool of Biology and Ecology, The University of Maine, Orono, ME, USA. jared.talbot@maine.edu.ORCID http://orcid.org/0000-0001-8941-6325

Funding

Regulation of Cellular Behavior in Response to Extracellular CuesP20GM144265 · NIGMS · UNIVERSITY OF MAINE ORONO · PI Benjamin L King · 2023 to 2026
$11.8M
Developmental regulation of oscillatory expressionR01GM117964 · NIGMS · OHIO STATE UNIVERSITY · PI AMACHER, SHARON L · 2015 to 2024
$2.6M
Targeted genome modification in zebrafish using zinc finger nucleasesR01GM088041 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI AMACHER, SHARON L · 2010 to 2012
$737k
The Role of Anillins in Gradient TrackingR15GM140409 · NIGMS · UNIVERSITY OF MAINE ORONO · PI KELLEY, JOSHUA BRIAN · 2021 to 2023
$528k
Investigating how Mylpf-regulated sarcomere formation influences limb skeletal developmentR15AR081019 · NIAMS · UNIVERSITY OF MAINE ORONO · PI TALBOT, JARED COFFIN · 2022 to 2022
$433k
NIAMS NIH HHS R15 AR081019NIGMS NIH HHS P20 GM144265NIGMS NIH HHS R01 GM088041NIGMS NIH HHS R01 GM117964NIGMS NIH HHS R15 GM140409U.S. Department of Health & Human Services | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) AR081019U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM088041U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM117964U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM140409U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) GM144265
6 · The paper itself

Abstract

Muscle becomes stronger by expanding sarcomeres from the cell's edge to its center. Here we investigate how Mylpf (Myosin Light Chain Phosphorylatable Fast) abundance impacts sarcomere growth. The two zebrafish Mylpf genes (mylpfa and mylpfb) are exclusively expressed in fast-twitch muscle, with mylpfa expressed more abundantly than mylpfb. Mutations in both genes cause full mRNA and protein loss, and loss of sarcomere formation. The degree of sarcomere reduction in fast-twitch muscle is predicted by Mylpf protein dosage using a high-slope Hill equation. The sarcomere defect may be driven by thick filament localization, which is impaired in mylpfa

Indexed as

Muscle Fibers, Fast-TwitchMyosin Light ChainsSarcomeresZebrafish ProteinsAnimalsHumansMutationZebrafishMyosin Light ChainsZebrafish Proteins

Identifiers

PMID42243126
PMCPMC13402835

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.