ArticleSchizophrenia (Heidelberg, Germany)2026
Cognitive subtypes and brain network differences in antipsychotic-naïve first-episode psychosis.
Article in Schizophrenia (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cognitive functioning within psychosis is heterogeneous, and data-driven approaches may help evaluate this heterogeneity. Brain network connectivity within first-episode psychosis (FEP) may provide an additional tool for understanding cognitive heterogeneity. FEP participants and healthy controls (HC) completed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and premorbid intellectual functioning was estimated using The American National Adult Reading Test (AmNART). k-means clustering of RBANS domain scores identified cognitive subgroups within FEP. Resting-state functional connectivity (FC) of the default mode (DMN), dorsal attention (DAN), executive control (ECN), and salience networks (SN) was assessed at baseline (prior to antipsychotic treatment), 6-, and 16 weeks. Voxelwise linear mixed models evaluated group-by-time interactions within each network. Two cognitive subgroups were identified within FEP (impaired and intact). All subjects had average premorbid intellectual functioning. At baseline, the cognitively impaired FEP subgroup showed reduced functional connectivity relative to healthy controls across regions within the DAN and ECN, with no significant differences observed between FEP subgroups (P
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