ArticleBioMed research international2026
Physicochemical Characterization, Cytotoxicity, and In Vivo Evaluation of a Hydroxyapatite-Silver Composite for Bone Regeneration.
Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Physicochemical Characterization, Cytotoxicity, and In Vivo Evaluation of a Hydroxyapatite-Silver Composite for Bone Regeneration.BioMed research international · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
This study is aimed at characterizing the physicochemical and biological properties of a hydroxyapatite-silver (HAp-Ag) composite for bone regeneration. HAp and HAp-Ag powders were analyzed using field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction and fluorescence, and Fourier transform infrared spectroscopy. Cylindrical pellets obtained by powder pressing and sintering were evaluated for fracture toughness, compressive strength, relative density, porosity, and wettability. Cell viability was assessed using the Alamar Blue assay. In the in vivo experiment, an 8-mm critical-size calvarial defect was surgically created in 36 male Wistar rats randomly divided into three groups: control group (CG), untreated defect; HAp group, defect filled with HAp pellet; and HAp-Ag group, defect filled with HAp-Ag pellet. Euthanasia was performed after 90 days, and calvaria samples were analyzed by μ-CT, histology, cytokine quantification, and gene expression analysis. The powders showed an irregular, agglomerated morphology, with HAp elements and silver detected in the HAp-Ag sample. Incorporation of Ag into HAp increased fracture toughness (0.66-0.94 MPa.m
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Registered trials
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