Evidence map›Paper›PMID 42242852›Full record

SynthesisAsia Pacific journal of clinical nutrition2026

Tart cherry intake and serum uric acid: Meta-analysis of randomized controlled trials and evidence from network pharmacology.

Zhenzhen Zhang, Zhiyuan Feng, Wei Yan, Tianyu Wu, Jiayue Xia, Junhui Yu, Jingyi Yang, Yuanyuan Wang, Guiju Sun

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Asia Pacific journal of clinical nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhenzhen ZhangKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene School of Public Health, Southeast University, Nanjing, China.
Zhiyuan FengKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene School of Public Health, Southeast University, Nanjing, China.
Wei YanKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene School of Public Health, Southeast University, Nanjing, China.
Tianyu WuKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene School of Public Health, Southeast University, Nanjing, China.
Jiayue XiaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene School of Public Health, Southeast University, Nanjing, China.
Junhui YuKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene School of Public Health, Southeast University, Nanjing, China.
Jingyi YangKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene School of Public Health, Southeast University, Nanjing, China.
Yuanyuan WangKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene School of Public Health, Southeast University, Nanjing, China.
Guiju SunKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene School of Public Health, Southeast University, Nanjing, China. Email: gjsun@seu.edu.cn.

Funding

National Key R&D Program of China 2023YFF1104402
6 · The paper itself

Abstract

BACKGROUND AND

objectivesTart cherry products have been proposed to lower serum uric acid and reduce gout risk, but clinical findings are inconsistent. This study evaluated the effect of tart cherry intake on serum uric acid concentration and explored possible mechanisms. METHODS AND STUDY

designRandomized controlled trials comparing tart cherry intake with placebo or usual diet and reporting serum uric acid concentration were identified from electronic databases. A random effects meta analysis was used to pool standardized mean differences between groups. In parallel, bioactive compounds in tart cherry were retrieved from public databases, and their potential targets related to serum uric acid and gout were investigated using network based analyses and molecular docking.

resultsFour randomized trials (eight comparisons; 392 participants) were included. Tart cherry intake was associated with a modest reduction in serum uric acid concentration compared with control (standardized mean difference -0.22; 95% confidence interval -0.43 to -0.01), with substantial heterogeneity. Network and docking analyses suggested that anthocyanins and other polyphenols may act on inflammatory, oxidative stress and metabolic pathways.

conclusionsTart cherry intake may modestly lower serum uric acid concentration, but evidence is limited in quantity and consistency. Larger, rigorously designed randomized trials are needed.

Indexed as

DietPrunus aviumUric AcidGoutHumansNetwork PharmacologyRandomized Controlled Trials as TopicUric Acidgoutmeta-analysisnetwork pharmacologyserum uric acid (sUA)tart cherry intake

Identifiers

PMID42242852
PMCPMC13236459

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.