Evidence map›Paper›PMID 42242830›Full record

Trial reportBMJ open respiratory research2026

Time spent within the SpO

Stephanie Ströbele, Tibor Jung, Dominik Kraft, Eva-Maria Mair, Sophie Kiener, Katharina Hofmann, Markus Waitz, Vanessa Linhoff, Antje Westhoff, Jens Dreyhaupt and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Stephanie StröbeleDivision of Neonatology and Pediatric Intensive Care Medicine, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.ORCID http://orcid.org/0009-0008-4741-3204
Tibor JungFaculty of Health Science, University of Applied Sciences Giessen Friedberg, Giessen, Germany.
Dominik KraftFaculty of Health Science, University of Applied Sciences Giessen Friedberg, Giessen, Germany.
Eva-Maria MairDivision of Neonatology and Pediatric Intensive Care Medicine, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Sophie KienerDivision of Neonatology and Pediatric Intensive Care Medicine, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Katharina HofmannDivision of Neonatology and Pediatric Intensive Care Medicine, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Markus WaitzDepartment of Neonatology, Kassel Hospital, Kassel, Germany.
Vanessa LinhoffFaculty of Health Science, University of Applied Sciences Giessen Friedberg, Giessen, Germany.
Antje WesthoffDepartment of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Jens DreyhauptInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Keywan SohrabiFaculty of Health Science, University of Applied Sciences Giessen Friedberg, Giessen, Germany.
Harald EhrhardtDivision of Neonatology and Pediatric Intensive Care Medicine, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany harald.ehrhardt@charite.de.ORCID http://orcid.org/0000-0003-4587-1734

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo study the efficacy of different modes of backup nasal intermittent positive pressure ventilation (NIPPV) during nasal continuous positive airway pressure (nCPAP) therapy to keep extremely preterm (EPT) infants within the oxygen saturation (SpO

designSingle-centre randomised cross-over trial.

settingLevel 3 neonatal intensive care unit.

participants24 EPT infants (median gestational age of 24+1 and median postnatal age of 43 days).

interventionsEPT infants on nCPAP therapy with backup NIPPV during apnoea >4 s were assigned in random sequence to immediate cessation of backup NIPPV or to stepwise reduction of backup NIPPV support on restart of spontaneous respiration.

main outcome measuresPrimary outcome was time spent within the SpO

resultsThe mean percentage of time spent within the SpO

conclusionOur findings underpin that new sophisticated ventilation modes like stepwise reduction of backup NIPPV do not necessarily provide a clinical benefit compared with the standard mode. For this, technological advances require robust evaluation within well-designed clinical trials demonstrating the safety and efficacy before being used in everyday clinical practice.

trial registrationGerman Clinical Trials Register; registration number: DRKS00031956 (https://drks.de/search/en/trial/DRKS00031956), date of registration: 26 May 2023.

Indexed as

Continuous Positive Airway PressureInfant, Extremely PrematureIntermittent Positive-Pressure VentilationOxygenOxygen SaturationRespiratory Distress Syndrome, NewbornCross-Over StudiesFemaleHumansInfant, NewbornIntensive Care Units, NeonatalMaleTime FactorsOxygenCritical CareNon invasive ventilationOxidative Stress

Identifiers

PMID42242830
PMCPMC13239443

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.