Evidence map›Paper›PMID 42242744›Full record

Observational studyBMJ open2026

Polyneuropathy in kidney transplant recipients: a cross-sectional study in Groningen, the Netherlands.

Svea Nolte, Harmen R Moes, Stephan J L Bakker, Celina Oldag, Fiete Lange, Bianca T A de Greef, Ilja M Nolte, Marco Van Londen, Jan-Willem J Elting, Catharina G Faber and 3 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04664426 (Adapted Modified Toronto Clinical Neuropathy Score and Erasmus Polyneuropathy Symptom Score Validated by Quantitative Sensory Testing and Nerve Conduction Studies for Kidney Transplant Recipients), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04664426 completednot on this map

Adapted Modified Toronto Clinical Neuropathy Score and Erasmus Polyneuropathy Symptom Score Validated by Quantitative Sensory Testing and Nerve Conduction Studies for Kidney Transplant Recipients

TypeobservationalSponsorUniversity Medical Center GroningenRan2021 to 2023Enrolled196ConditionsPolyneuropathies
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Svea NolteDepartment of Neurology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands s.nolte@umcg.nl.ORCID http://orcid.org/0000-0003-4742-1446
Harmen R MoesDepartment of Neurology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Stephan J L BakkerDepartment of Internal Medicine, Division of Nephrology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Celina OldagDepartment of Neurology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Fiete LangeDepartment of Neurology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Bianca T A de GreefDepartment of Neurology, Mental Health & Neuroscience Research Institute, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Ilja M NolteDepartment of Epidemiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Marco Van LondenDepartment of Internal Medicine, Division of Nephrology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-7145-3240
Jan-Willem J EltingDepartment of Neurology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Catharina G FaberDepartment of Neurology, Mental Health & Neuroscience Research Institute, Maastricht University Medical Centre+, Maastricht, The Netherlands.
Pieter A Van DoornDepartment of Neurology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.
Stefan P BergerDepartment of Internal Medicine, Division of Nephrology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Gea DrostDepartment of Neurology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine the prevalence and clinical characteristics associated with polyneuropathy in kidney transplant recipients (KTRs).

designCross-sectional study.

settingSENS study at the University Medical Center Groningen, the Netherlands, December 2021-May 2023.

participantsKTR, participating in the ongoing TransplantLines Biobank and Cohort Study, ≥12 months post-transplantation.

main outcome measuresParticipants underwent a structured neurological assessment including history taking, neurological examination, quantitative sensory testing and nerve conduction studies. An expert panel classified participants into no/possible, probable/definite large fibre polyneuropathy or small fibre neuropathy. Large-fibre subtypes included axonal or demyelinating, pure sensory, pure motor and sensorimotor. To assess potential associations with clinical characteristics, logistic regression analysis was conducted.

resultsWe included 160 KTRs with a mean age of 59.8±11.6 years at a median of 6.1 (95% CI 3.9 to 13.1) years post-transplantation, with 16 KTRs (10%) diagnosed with polyneuropathy before study inclusion. In total, 84 KTRs (53%) were identified with large fibre polyneuropathy and 7 KTRs (4%) with small fibre neuropathy. KTRs with large fibre polyneuropathy presented with either sensor-predominant polyneuropathy (40 KTR (48%)) or sensorimotor polyneuropathy (44 KTR (52%)). We found no neurophysiological characteristics of demyelination. Overall, 18% (95% CI 11% to 27%) of KTRs with large fibre polyneuropathy were asymptomatic. Higher age (OR=1.04 (1.01 to 1.08), p=0.01), male sex (OR=2.55 (1.19 to 5.60), p=0.02), diabetes (OR=5.58 (1.36 to 38.14), p=0.03) and elevated urea levels (OR=1.12 (1.04 to 1.23), p=0.01) were significantly associated with polyneuropathy in KTR.

conclusionsIn contrast with previous studies, axonal sensory or sensorimotor polyneuropathy is highly prevalent and often underdiagnosed in KTR. Next to higher age and male sex, it was independently associated with diabetes and higher urea levels. Further research is needed to reveal the aetiology and course of polyneuropathy in KTRs. TRIAL REGISTRATION NUMBER: NCT04664426.

Indexed as

Kidney TransplantationPolyneuropathiesAgedCross-Sectional StudiesFemaleHumansLogistic ModelsMaleMiddle AgedNerve Conduction StudiesNetherlandsNeural ConductionNeurologic ExaminationPrevalenceNephrologyNeurologyNeurophysiologyRenal transplantation

Identifiers

PMID42242744
PMCPMC13239384

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.