Evidence map›Paper›PMID 42242738›Full record

ArticleBMJ open2026

Early health technology assessment (eHTA) approaches focused on human stem cell-related technologies: a scoping review protocol.

Troy Francis, Samah Hassan, Joanna Bielecki, Anwar Abdi, Utovia Stewart, Michael A Laflamme, Valeria Rac

Abstract read
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Troy FrancisProgram for Health System and Technology Evaluation, University Health Network, Toronto, Ontario, Canada troy.francis@theta.utoronto.ca.ORCID http://orcid.org/0000-0002-7259-0922
Samah HassanProgram for Health System and Technology Evaluation, University Health Network, Toronto, Ontario, Canada.
Joanna BieleckiProgram for Health System and Technology Evaluation, University Health Network, Toronto, Ontario, Canada.
Anwar AbdiProgram for Health System and Technology Evaluation, University Health Network, Toronto, Ontario, Canada.
Utovia StewartProgram for Health System and Technology Evaluation, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0009-0001-3812-6560
Michael A LaflammeMcEwen Stem Cell Institute, University Health Network, Toronto, Ontario, Canada.
Valeria RacProgram for Health System and Technology Evaluation, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-0426-4594

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe growing advancement of innovative stem cell technologies requires careful evaluation of their economic, clinical and societal impacts. Early economic evaluations are essential for developing new medical technologies and supporting key decisions about commercialisation and market access. This scoping review explores Early Health Technology Assessment (eHTA) approaches specifically related to human stem cell technologies. By examining how eHTA can support the commercialisation of these therapies, we aim to clarify its role in optimising resource allocation and enhancing both the clinical and societal benefits of stem cell technologies. METHODS AND ANALYSIS: To explore the use of eHTA in the development of stem cell-related technologies, a scoping review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses - Scoping Review Extension guidelines. Systematic searches were conducted across scientific databases (MEDLINE, International HTA database, EconLit, PAIS Index and EconPapers), grey literature sources (Overton) and through hand-searching to identify eligible articles published from inception to 14 April 2026. No limits were imposed on language. Reviewers will independently record data from eligible studies using a standard data abstraction form. The gathered information will be synthesised both quantitatively and narratively. ETHICS AND DISSEMINATION: Formal ethical approval is not required, as this study does not involve the collection of primary data. The findings will be shared through professional stem cell networks, published in national and international health technology assessment conference proceedings and submitted for open-access, peer-reviewed publication.

Indexed as

Stem CellsStem Cell TransplantationTechnology Assessment, BiomedicalCost-Benefit AnalysisHumansResearch DesignScoping Reviews as TopicHealth economicsHealth ServicesMesenchymal Stem Cells

Identifiers

PMID42242738
PMCPMC13239643

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.