Evidence map›Paper›PMID 42242608›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2026

Fully self-gated dual-venc five-dimensional flow magnetic resonance imaging for simultaneous imaging of the cardiovascular and portal venous systems: A feasibility study.

Yuyang Ren, Wen Ye, Wenchao Yang, Wenjian Liu, Haotian Hong, Junpu Hu, Jiayu Zhu, Haikun Qi, Fei Shan, Peng Hu and 1 more

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Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yuyang RenSchool of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China.
Wen YeDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Wenchao YangUnited Imaging Healthcare, Shanghai, China.
Wenjian LiuSchool of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China.
Haotian HongSchool of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China.
Junpu HuUnited Imaging Healthcare, Shanghai, China.
Jiayu ZhuUnited Imaging Healthcare, Shanghai, China.
Haikun QiSchool of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China; Shanghai Clinical Research and Trial Center, ShanghaiTech University, Shanghai, China.
Fei ShanDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China. Electronic address: shanfei@shaphc.org.
Peng HuSchool of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China; Shanghai Clinical Research and Trial Center, ShanghaiTech University, Shanghai, China. Electronic address: hupeng@shanghaitech.edu.cn.
Zijian ZhouSchool of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China. Electronic address: zhouzj@shanghaitech.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo develop and evaluate a fully self-gated dual-venc five-dimensional (5D) flow cardiovascular magnetic resonance (CMR) technique for joint assessment of cardiovascular and portal venous hemodynamics under free breathing.

methodsA dual-venc 5D flow sequence using a spiral-in Cartesian sampling trajectory was implemented. Cardiac and respiratory motion were retrospectively resolved using principal component analysis of self-gating signals, followed by total variation regularized reconstruction. The technique was first tested in a custom-built phantom with steady flow and stationary parts, and compared with conventional four-dimensional (4D) flow. It was then evaluated in healthy volunteers and in patients with cirrhosis or portal hypertension, including post-transjugular intrahepatic portosystemic shunt (TIPS) cases. No contrast agent was administered for either the phantom or in vivo scans, with an in vivo 5D flow scan time of approximately 15 min per subject. Hemodynamic parameters in both the cardiovascular and portal venous systems were quantified and compared with conventional breath-held, ECG-triggered two-dimensional (2D) phase-contrast (PC) MRI. For each subject, flow internal consistency (IC) across vessel planes and respiration-resolved flow variations were also computed.

resultsPhantom experiments demonstrated an average 67% improvement in velocity-to-noise ratio (VNR) and similar flow quantification compared with fully sampled 4D flow MRI. In vivo evaluation included 12 healthy volunteers, 8 cirrhosis patients, and 9 post-TIPS patients. Across all cohorts, dual-venc 5D flow achieved substantial VNR enhancement (approximately 200% on average), high flow IC (>82%), and strong agreement with 2D PC MRI for both peak and net flow (bias <10%). Respiration-resolved analysis revealed a consistent increase in net flow in the main pulmonary artery (MPA), right pulmonary artery (RPA), and superior vena cava (SVC) during inspiration, along with elevated SVC peak flow.

conclusionsFully self-gated dual-venc 5D flow MRI enables simultaneous, respiration-resolved quantification of cardiovascular and portal venous hemodynamics within a clinically feasible scan time and with high VNR. This technique provides a promising tool for characterizing systemic hemodynamics in cirrhosis and for evaluating portal-systemic circulatory interactions following TIPS.

Indexed as

5D flowCardiovascular hemodynamicsCirrhosisDual-vencPortal venous systemRespiratory-resolved flow

Identifiers

PMID42242608
PMCPMC13292760

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.