ArticleJournal of clinical periodontology2026
Periodontitis and Endotoxemia: Clinical and Microbiological Insights.
Article in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Machine Learning Stratification of Periodontal and Cerebrovascular Disease Status Using Salivary and Subgingival Lipopolysaccharide Activity.Journal of cellular and molecular medicine · 2026Article
- The oral‒gut axis in periodontal disease: a systematic review of the associated human evidence of its mechanisms and implications for patient care.Journal of oral microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
aimEndotoxemia has been proposed as a link between periodontitis and systemic complications through the translocation of lipopolysaccharide (LPS) from inflamed periodontal sites into the bloodstream. This study aimed to investigate subgingival and serum LPS activities and their correlations with periodontal clinical and microbiological parameters. MATERIALS AND
methodsTwo-hundred and seventy participants with gingivitis and periodontitis from the SECRETO Oral cohort were included in the study. Serum and subgingival plaque samples were analysed for LPS activity using the recombinant Factor C assay, and subgingival microbiota were profiled by 16S rRNA sequencing. Dysbiosis indices and taxonomic associations were assessed through multivariate regressions and MaAsLin2 models adjusted for clinical and demographic covariates. Functional pathways were inferred using PICRUSt2.
resultsSerum LPS activities were significantly elevated in periodontitis patients compared to gingivitis patients and correlated with the subgingival microbial dysbiosis index (SMDI). Subgingival LPS was also significantly higher in periodontitis patients and showed strong associations with subgingival bacterial load and SMDI. Subgingival LPS explained 10% of serum LPS variations. Differential abundance analysis identified Fretibacterium as positively associated with both subgingival and serum LPS activities. Functional prediction revealed enrichment of bacterial motility and invasion pathways, with depletion of host defence functions, supporting a mechanistic link between subgingival dysbiosis, LPS translocation and systemic endotoxemia.
conclusionThese findings provide novel evidence that elevated serum LPS activities are closely linked with periodontitis diagnosis, associated with subgingival dysbiosis, and highlight the periodontal niche as a source of systemic endotoxemia. In addition, it identified Fretibacterium as the main contributor to both subgingival and serum LPS activities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.