Evidence map›Paper›PMID 42242229›Full record

ArticleCell reports. Medicine2026

STAT3 interference-driven nanomodulators reverse lipid metabolism-associated chemoresistance and potentiate metalloimmunotherapy in breast cancer.

Zifan Pei, Yifan Yin, Nailin Yang, Shumin Sun, Nan Jiang, Fangyi Yu, Xiaofen Zhang, Jihu Nie, Youdong Chen, Longxiao Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zifan PeiInstitute of Functional Nano and Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, 199 Ren'Ai Rd., Suzhou 215123, China.
Yifan YinDepartment of General Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201112, China; Department of Urology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Nailin YangInstitute of Functional Nano and Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, 199 Ren'Ai Rd., Suzhou 215123, China.
Shumin SunInstitute of Functional Nano and Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, 199 Ren'Ai Rd., Suzhou 215123, China.
Nan JiangDepartment of Interventional Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Fangyi YuInstitute of Functional Nano and Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, 199 Ren'Ai Rd., Suzhou 215123, China.
Xiaofen ZhangInstitute of Functional Nano and Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, 199 Ren'Ai Rd., Suzhou 215123, China.
Jihu NieInstitute of Functional Nano and Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, 199 Ren'Ai Rd., Suzhou 215123, China.
Youdong ChenInstitute of Functional Nano and Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, 199 Ren'Ai Rd., Suzhou 215123, China.
Longxiao LiInstitute of Functional Nano and Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, 199 Ren'Ai Rd., Suzhou 215123, China.
Jie WuInstitute of Functional Nano and Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, 199 Ren'Ai Rd., Suzhou 215123, China.
Fei GongInstitute of Functional Nano and Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, 199 Ren'Ai Rd., Suzhou 215123, China.
Minming ChenInstitute of Functional Nano and Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, 199 Ren'Ai Rd., Suzhou 215123, China.
Wei LiuDepartment of General Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 201112, China.
Liang ChengInstitute of Functional Nano and Soft Materials (FUNSOM), Biomedical-BasicResearch-Center (BBRC) of Jiangsu Province, Soochow University, 199 Ren'Ai Rd., Suzhou 215123, China. Electronic address: lcheng2@suda.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical evidence has suggested that persistent STAT3 activation and alteration in lipid metabolism correlate with pathological progression in patients with breast cancer, driving resistance to chemotherapy. Herein, we show that H

Indexed as

Breast NeoplasmsDrug Resistance, NeoplasmImmunotherapyLipid MetabolismSTAT3 Transcription FactorAnimalsCell Line, TumorFemaleHumansHydrogen SulfideMiceNickelSignal TransductionHydrogen SulfideNickelSTAT3 protein, humanSTAT3 Transcription Factorbreast cancerchemotherapyH(2)SmetalloimmunotherapySTAT3αPD-1

Identifiers

PMID42242229
PMCPMC13293998

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.