Evidence map›Paper›PMID 42242217›Full record

ArticleNeuron2026

A specialized population of hair afferents dedicated to transmitting mechanical itch.

Mahar Fatima, Hankyu Lee, Hwayeon Cha, Chia Chun Hor, Feng Wang, Jingyi Liu, Jonathan Damblon, Wenwen Zhang, Katie Qu, Yumena Nagai and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Mahar FatimaDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Hankyu LeeDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Hwayeon ChaDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Chia Chun HorDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Feng WangDepartment of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Québec, QC, Canada.
Jingyi LiuDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Jonathan DamblonDepartment of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Québec, QC, Canada.
Wenwen ZhangLife Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Katie QuDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Yumena NagaiDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Abbey DinhDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Ziyan WuDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Ranveer AjimalDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Ailin Emily XiongDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Madeleine ChaiDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Alyssa AsmarDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Wei CaiLife Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Xiaowei ZhouDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Anuraag BalajiDepartment of Dermatology, Department of Computational Medicine & Bioinformatics, Department of Biostatistics, Mary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI 48109, USA.
Haili PanDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Lorraine HorwitzDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Lam C TsoiDepartment of Dermatology, Department of Computational Medicine & Bioinformatics, Department of Biostatistics, Mary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI 48109, USA.
Hongzhen HuDepartment of Dermatology and Neuroscience, The Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
X Z Shawn XuLife Sciences Institute, Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Yves De KoninckDepartment of Psychiatry and Neuroscience, CERVO Brain Research Centre, Université Laval, Québec, QC, Canada.
Bo DuanDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: bduan@umich.edu.

Funding

An unexpected role of glutamate receptors in the peripheral nervous systemR01NS118769 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DUAN, BO, XU, SHAWN · 2020 to 2024
$2.6M
Dissecting neural circuits for mechanical itchR01NS109170 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DUAN, BO · 2019 to 2023
$2.2M
Spinal Circuit Mechanisms of Visceral Sensory Transmission and RegulationR56DK139477 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DUAN, BO, HU, HONGZHEN · 2024 to 2024
$726k
NIDDK NIH HHS R56 DK139477NINDS NIH HHS R01 NS109170NINDS NIH HHS R01 NS118769
6 · The paper itself

Abstract

Hairs serve as sensory structures that are crucial for perceiving environmental cues through interactions with sensory endings. Depigmented and demedullated atypical hairs exhibit a limited distribution on mammalian skin and have not been extensively studied. In this study, we identify a specific type of hair, termed vellus-like hairs (VLHs), which are enriched in the postauricular region and on the hindpaws of mice. These hairs are innervated by Aβ low-threshold mechanoreceptors (LTMRs) that co-express Toll-like receptor 5 and Calbindin1 (TLR5

Indexed as

chronic itchdorsal root ganglionmechanical itchPiezo2TLR5(Calb1) Aβ-LTMRsvellus-like hair

Identifiers

PMID42242217
PMCPMC13383664

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.