ArticleStem cell reports2026
PCBP1 orchestrates amino acid metabolism burst during the naïve-to-primed pluripotency transition.
Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Colorectal cancer-associated PCBP1 mutations disrupt protein stability in a dominant negative manner.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Embryo implantation is accompanied by the naïve-to-primed pluripotency state transition in epiblast cells-the process involving proliferation and anabolic boost, needed for extensive embryo growth. Here, we show that Pcbp1 knockout leads to embryo growth arrest shortly after implantation. By modeling the naïve-to-primed pluripotency transition in vitro, we observe impaired proliferation and induction of apoptosis in cells deficient for PCBP1. Using multi-omics approaches, we reveal a crucial role for PCBP1 in driving a transcriptional burst of numerous genes involved in the import and the de novo synthesis of essential and conditionally essential amino acids. PCBP1 deficiency is consequently associated with a slowdown in protein biosynthesis, which explains the early lethality of the knockout embryos. Our findings thus uncover the molecular mechanisms underlying anabolic changes during the naïve-to-primed pluripotency transition and highlight the essential role of PCBP1 in this critical process.
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