Evidence map›Paper›PMID 42242188›Full record

ArticleCell stem cell2026

Closing the gap: Toward functional, bioengineered esophageal grafts.

Dominique D Bailey, Jianwen Que

Abstract read
In one paragraph

Article in Cell stem cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Dominique D BaileyDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Columbia University Vagelos College of Physicians & Surgeons and New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY 10032, USA; Columbia Center for Human Development, Columbia University Medical Center, New York, NY 10032, USA.
Jianwen QueDivision of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY 10032, USA; Columbia Center for Human Development, Columbia University Medical Center, New York, NY 10032, USA. Electronic address: jq2240@cumc.columbia.edu.

Funding

SOX4-Mediated Transcription Program in Esophageal AdenocarcinomaP01CA268991 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WAEL EL-RIFAI · 2022 to 2026
$9.2M
Gastroesophageal junction stem cells as the origin of Barretts esophagus and cancerR01CA272901 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUE, JIANWEN, WANG, TIMOTHY CRAGIN · 2022 to 2025
$4.9M
Post-transcriptional modification in esophageal basal cells.R01DK144271 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jianwen Que · 2025 to 2026
$1.6M
Molecular Mechanisms of Reactive Epithelial Changes in Pediatric Eosinophilic EsophagitisK08DK128603 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BAILEY, DOMINIQUE · 2021 to 2025
$903k
Investigation of epithelial cell biology in preclinical mouse models of early-onset EoER03DK145963 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Dominique Bailey · 2026 to 2026
$123k
NCI NIH HHS P01 CA268991NCI NIH HHS R01 CA272901NIDDK NIH HHS K08 DK128603NIDDK NIH HHS L40 DK122475NIDDK NIH HHS R01 DK144271NIDDK NIH HHS R03 DK145963
6 · The paper itself

Abstract

In a recent Nature Biotechnology paper, Pablo De Coppi et al. integrate tissue engineering with organ transplantation in a porcine model. They demonstrate that microinjection of autologous myogenic precursors and fibroblasts into a decellularized porcine scaffold, followed by bioreactor maturation, yields a graft that functionally integrates with the native esophagus.

Indexed as

EsophagusTissue EngineeringAnimalsHumansSwineTissue Scaffolds

Identifiers

PMID42242188
PMCPMC13312429

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.