Evidence map›Paper›PMID 42242006›Full record

ReviewCurrent opinion in immunology2026

Hantavirus on the rise: clinical, virological, immunological, and public health perspectives.

Arpan Acharya, Swathi P Murakonda, Debapriya Sutar, Siddappa N Byrareddy

Abstract readReview
In one paragraph

Review in Current opinion in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Arpan AcharyaDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE 68198, USA.
Swathi P MurakondaDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE 68198, USA.
Debapriya SutarDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE 68198, USA.
Siddappa N ByrareddyDepartment of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, NE 68198, USA. Electronic address: sid.byrareddy@unmc.edu.

Funding

Epigenetic mechanisms underlying cannabinoid modulation of neuroinflammation in HIV/SIV infection-supplementR01DA052845 · NIDA · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI BYRAREDDY, SIDDAPPA N, MOHAN, MAHESH · 2020 to 2024
$4.0M
Limiting HIV establishment and maintenace by preserving intestinal immunityR01AI129745 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BYRAREDDY, SIDDAPPA N, PAIARDINI, MIRKO · 2017 to 2020
$3.3M
Sex differences in modulating HIV/SIV reservoirs in the context of opioidsR01DA061678 · NIDA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Siddappa N Byrareddy · 2024 to 2026
$2.0M
SIV reservoirs dynamics during agingR21OD037751 · OD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ACHARYA, ARPAN · 2024 to 2025
$600k
NIAID NIH HHS R01 AI129745NIDA NIH HHS R01 DA052845NIDA NIH HHS R01 DA061678NIH HHS R21 OD037751
6 · The paper itself

Abstract

Hantaviruses are enveloped, negative-sense RNA viruses. Rodents serve as natural reservoirs, and spillover into humans causes hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. While transmission typically occurs by inhaling aerosolized rodent excreta, the Andes virus variant is capable of human-to-human transmission. A recent outbreak involving a person-to-person transmission cluster aboard the cruise ship MV Hondius has underscored the urgency of hantavirus preparedness. Immediate global pandemic risk remains low because sustained transmission requires prolonged close contact, and hantavirus has low environmental stability compared to other RNA viruses with pandemic potential. However, climate change, deforestation, and urbanization increase human-rodent interactions and spillover risks. Additionally, prolonged incubation in immunocompromised individuals, including people with Human Immunodeficiency Virus (PWH) and other chronic conditions, may facilitate viral adaptation, potentially leading to strains with enhanced transmissibility. We review hantavirus classification, epidemiology, transmission dynamics, immunopathology, treatment strategies, the urgent need for global surveillance, and accelerated vaccines and prophylactic development.

Indexed as

Hantavirus InfectionsOrthohantavirusAnimalsDisease ReservoirsHumansPublic Health

Identifiers

PMID42242006
PMCPMC13318062

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.