Evidence map›Paper›PMID 42241732›Full record

ArticleEBioMedicine2026

Genome-wide association study of paediatric bacteraemia and sepsis.

Dylan Lawless, Flavia Aurelia Hodel, Christian W Thorball, Zhi Ming Xu, Alessandro Borghesi, Eric Giannoni, Johannes Trück, Martin Stocker, Klara M Posfay-Barbe, Ulrich Heininger and 12 more

Abstract read
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In one paragraph

Article in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Dylan LawlessDepartment of Intensive Care and Neonatology, and Children's Research Center, University Children's Hospital Zürich, University of Zürich, Zurich, Switzerland.
Flavia Aurelia HodelPrecision Medicine Unit, Biomedical Data Science Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Christian W ThorballPrecision Medicine Unit, Biomedical Data Science Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Zhi Ming XuGlobal Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Alessandro BorghesiGlobal Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Neonatal Intensive Care Unit, San Matteo Research Hospital, Pavia, Italy; Neonatal Unit, Geneva University Hospitals, Mother, Child and Adolescent Department, Geneva, Switzerland.
Eric GiannoniClinic of Neonatology, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Johannes TrückDivisions of Allergy and Immunology, University Children's Hospital Zurich and Children's Research Center, University of Zürich, Zurich, Switzerland.
Martin StockerPediatric Intensive Care and Neonatology, Children's Hospital of Central Switzerland and University of Lucerne, Lucerne, Switzerland.
Klara M Posfay-BarbePediatric Infectious Diseases Unit, Children's Hospital of Geneva, University Hospitals of Geneva, Geneva, Switzerland.
Ulrich HeiningerInfectious Diseases and Vaccinology, University of Basel Children's Hospital, Basel, Switzerland.
Sara Bernhard-StirnemannChildren's Hospital Aarau, Aarau, Switzerland.
Anita Niederer-LoherDivision of Infectious Diseases and Infection Control, Children's Hospital of Eastern Switzerland St. Gallen, St. Gallen, Switzerland.
Christian R KahlertDivision of Infectious Diseases and Infection Control, Children's Hospital of Eastern Switzerland St. Gallen, St. Gallen, Switzerland.
Giancarlo NatalucciDepartment of Neonatology, University Hospital Zürich, Zurich, Switzerland.
Christa RellyDivision of Infectious Diseases and Hospital Epidemiology, and Children's Research Center, University Children's Hospital Zürich, Zurich, Switzerland.
Christoph BergerDivision of Infectious Diseases and Hospital Epidemiology, and Children's Research Center, University Children's Hospital Zürich, Zurich, Switzerland.
Thomas RiedelDivision of Infectious Disease, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Christoph AebiDivision of Infectious Disease, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Philipp AgyemanDivision of Infectious Disease, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Jacques FellayPrecision Medicine Unit, Biomedical Data Science Center, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland; Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland. Electronic address: jacques.fellay@epfl.ch.
Luregn J SchlapbachDepartment of Intensive Care and Neonatology, and Children's Research Center, University Children's Hospital Zürich, University of Zürich, Zurich, Switzerland; Child Health Research Centre, The University of Queensland, Brisbane, Australia. Electronic address: Luregn.Schlapbach@kispi.uzh.ch.
Swiss Pediatric Sepsis Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSepsis is defined as a dysregulated host response to infection leading to organ dysfunction. It represents a major global health concern, particularly in childhood. The underlying pathophysiological and genetic mechanisms remain insufficiently understood.

methodsUsing samples and clinical data from 650 children enrolled in the Swiss Pediatric Sepsis Study, a national multicentre cohort for culture-proven bacterial sepsis, we conducted within-cohort analyses and a separate case-control analysis in 510 cases and 994 controls, testing genome-wide polymorphisms for association with sepsis susceptibility and, in cases only, with disease characteristics.

findingsIn the within-cohort analysis, no significant genome-wide associations were found when assessing host, microbiological, and outcome features. In the case-control analysis, we identified one locus significantly associated with sepsis susceptibility, encompassing the CTNNAL1 and ELP1 genes.

interpretationOur results suggest contribution of genetic modulators to susceptibility for sepsis in children.

fundingThe Swiss Pediatric Sepsis Study received funding from the Swiss National Science Foundation (342730_153158/1 and 320030_201060/1), the Swiss Society of Intensive Care, the Bangerter Foundation, the Vinetum and Borer Foundation, the Foundation for the Health of Children and Adolescents, and the Sanofi-Aventis Suisse. LJS was supported by the NOMIS and the Thomas and Doris Ammann Foundation.

Indexed as

BacteremiaGenome-Wide Association StudySepsisAdolescentCase-Control StudiesChildChild, PreschoolFemaleGenetic Predisposition to DiseaseHumansInfantMalePolymorphism, Single NucleotideBacteraemiaCTNNAL1ELP1Genome-wide association studyPaediatricSepsis

Identifiers

PMID42241732
PMCPMC13266212

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.