ArticlePloS one2026
Association of leuko-glycemic index with mortality in ICU patients with Acute kidney injury: A retrospective multicenter cohort study.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute kidney injury (AKI) complicates the course of critical illness and carries high short- and long-term mortality rates; however, reliable early prognostic markers remain limited. The leuko-glycemic index (LGI), the product of white blood cell counts and blood glucose, has shown prognostic value in other acute conditions; however, its role in intensive care unit (ICU) patients with AKI remains unexplored.
methodsIn this multicenter retrospective cohort study, we analyzed 112,235 adult ICU admissions from the MIMIC-IV (n = 54,840) and eICU-CRD (n = 57,395) databases. Patients with multiple ICU stays and those aged <18 years were excluded. The LGI was calculated within 24 h of admission and stratified into quartiles (Q1-Q4). The primary endpoints were 30- and 90-day in-hospital mortality, and the secondary endpoint was overall in-hospital mortality. Kaplan-Meier survival curves, multivariable Cox proportional hazards models, and restricted cubic splines (RCS) assess the association between LGI and outcomes, with subgroup and interaction analyses for key comorbidities.
resultsHigher LGI quartiles were associated with progressively worse survival (p < 0.0001). In the fully adjusted models, each unit increase in LGI conferred a small but significant rise in 30-day (HR 1.01; 95% CI 1.01-1.01) and 90-day mortality (HR 1.01; 95% CI 1.01-1.01), while Q4 versus Q1 yielded HRs of 1.22 (95% CI 1.13-1.31) and 1.21 (95% CI 1.13-1.30), respectively. RCS demonstrated a nonlinear relationship, and the associations persisted across subgroups.
conclusionLGI may be an independent biomarker associated with short-term mortality in ICU patients with AKI. Its potential clinical relevance warrants further investigation and validation in larger cohorts.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.