Evidence map›Paper›PMID 42241341›Full record

ArticleIndian journal of ophthalmology2026

Anterior segment optical coherence tomography-guided assessment of wound healing after cyanoacrylate glue patch for corneal perforations.

Manpreet Kaur, Vaibhav Namdev, Silpa Lalu, Sarath S Pillai, Jeewan S Titiyal

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Article in Indian journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Manpreet KaurCornea, Cataract and Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Vaibhav NamdevCornea, Cataract and Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Silpa LaluCornea, Cataract and Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Sarath S PillaiDepartment of Ophthalmology, Chaithanya Eye Hospital and Research Institute, Kesavadasapuram, Thiruvananthapuram, Kerala, India.
Jeewan S TitiyalCornea, Cataract and Refractive Surgery Services, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate wound healing after cyanoacrylate glue patch (CGP) application in corneal perforations using anterior segment optical coherence tomography (ASOCT).

designProspective interventional case series.

methodsTwenty-eight patients with corneal perforations (<4 mm) underwent CGP application. The primary outcome measure was wound healing pattern on ASOCT after CGP application. Secondary outcomes were time to removal of CGP and anatomical success. Follow-up was performed on POD 1 and every 2 weeks till CGP removal.

resultsThree distinct wound healing patterns were observed on ASOCT: Type 1 with corrugated hyper-reflective mass corresponding to CGP with underlying shadowing, Type 2 pattern with ongoing stromal regeneration without continuity with surrounding healthy cornea, and Type 3 with complete stromal regeneration beneath the CGP continuous with surrounding cornea. On POD 1, 100% cases had type 1 pattern. At 2 weeks, 85.7% had type 2; 14.3% had type 1 pattern. At 4 weeks, 35.7% cases had type 3 and 64.3% had type 2 pattern. Five cases underwent early glue removal (type 2 pattern) at 31.8 ± 2.5 days because of CGP intolerance; of these, 40% (2/5) developed a leak and required reapplication of CGP. Total 82.1% cases achieved type 3 pattern by 8 weeks. CGP was removed after documentation of type 3 pattern in 82.1% cases at 41.7 ± 9.2 days; no case developed wound leak.

conclusionsASOCT is a useful adjunct to objectively monitor wound healing after CGP and guide regarding optimal timing for its removal, with type 3 pattern correlating with higher anatomical success.

Indexed as

Anterior Eye SegmentCorneal PerforationCyanoacrylatesTissue AdhesivesTomography, Optical CoherenceWound HealingAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesVisual AcuityCyanoacrylatesTissue AdhesivesAnterior segment optical coherence tomographyASOCTcorneal perforationcyanoacrylate gluewound healing

Identifiers

PMID42241341
PMCPMC13529033

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.