Evidence map›Paper›PMID 42241317›Full record

ArticleeLife2026

Quantitative RNA pseudouridine landscape reveals dynamic modification patterns and evolutionary conservation across bacterial species.

Letong Xu, Shenghai Shen, Yizhou Zhang, Zhihao Guo, Beifang Lu, Jiadai Huang, Runsheng Li, Yitong Shen, Li-Sheng Zhang, Xin Deng

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Compendium of RNA modifications for bacterial stress adaptation.Microbiology and molecular biology reviews : MMBR · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Letong Xu *Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0009-0001-8897-0591
Shenghai Shen *Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.ORCID https://orcid.org/0000-0001-8422-5423
Yizhou ZhangDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
Zhihao GuoShenzhen Research Institute, City University of Hong Kong, Shenzhen, China.
Beifang LuDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
Jiadai HuangDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
Runsheng LiTung Biomedical Sciences Center, City University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0003-1563-1844
Yitong ShenDivision of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.
Li-Sheng ZhangDivision of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China.
Xin DengDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.ORCID https://orcid.org/0000-0003-1580-0089

Funding

Early Career Scheme of Hong Kong 26103623General Research Funds of Hong Kong 11101619General Research Funds of Hong Kong 11102720General Research Funds of Hong Kong 21103018Guangdong Major Project of Basic and Applied Basic Research 2020B0301030005National Natural Science Foundation of China 32172358
6 · The paper itself

Abstract

Pseudouridine (Ψ) modifications are the most abundant RNA modifications; however, their distribution and functional significance in bacteria remain largely unexplored compared to eukaryotic systems. In this study, we present the first transcriptome-wide and quantitative mapping of Ψ modifications across five diverse bacterial species (

Indexed as

BacteriaEvolution, MolecularPseudouridineRNA, BacterialRNA Processing, Post-TranscriptionalBacillus cereusEscherichia coliPseudomonas syringaeRNA, MessengerRNA, TransferPseudouridineRNA, BacterialRNA, MessengerRNA, TransferBacillus cereusEscherichia coliinfectious diseaseKlebsiella pneumoniaemicrobiologyPseudomonas aeruginosaPseudomonas syringae

Identifiers

PMID42241317
PMCPMC13236023

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.