Evidence map›Paper›PMID 42241288›Full record

ArticleCell reports2026

NRF2-mediated inhibition of alveolar macrophage MHC II expression during Mycobacterium tuberculosis infection.

Linh K Pham, Maritza M Cervantes, Pamelia N Lim, Divya Dubey, Ankita Tufts, M Clare Mitchell, Tomoyo Shinkawa, Samuel M Behar, Alissa C Rothchild

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. HowVaccines · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Linh K PhamDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA; Animal Biotechnology & Biomedical Sciences Graduate Program, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Maritza M CervantesDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Pamelia N LimDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Divya DubeyDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Ankita TuftsDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.
M Clare MitchellDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA.
Tomoyo ShinkawaDepartment of Microbiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Samuel M BeharDepartment of Microbiology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.
Alissa C RothchildDepartment of Veterinary and Animal Sciences, University of Massachusetts Amherst, Amherst, MA 01003, USA. Electronic address: arothchild@umass.edu.

Funding

Regulation of CD8+ T cell immunity to tuberculosis (pending title)R01AI106725 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M · 2013 to 2022
$6.1M
Biotechnology Training Program in Applied Life SciencesT32GM135096 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Jeanne Ann Hardy, Ashish A. Kulkarni · 2020 to 2026
$3.9M
Innate sensing of M. tuberculosis by alveolar macrophagesR01AI177653 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Alissa Chen Rothchild · 2024 to 2026
$1.4M
Nrf2 regulation of alveolar macrophage immune responses in vivo to Mycobacterium tuberculosisR21AI163809 · NIAID · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ROTHCHILD, ALISSA CHEN · 2022 to 2023
$429k
NIAID NIH HHS R01 AI106725NIAID NIH HHS R01 AI177653NIAID NIH HHS R21 AI163809NIGMS NIH HHS T32 GM135096
6 · The paper itself

Abstract

During Mycobacterium tuberculosis (Mtb) infection, infected alveolar macrophages (AMs) initially up-regulate a nuclear factor erythroid 2-related factor 2 (NRF2)-regulated cell-protective program, which is detrimental to host control and impedes AM activation, including MHC II expression. MHC II is critical for CD4

Indexed as

Histocompatibility Antigens Class IIMacrophages, AlveolarMycobacterium tuberculosisNF-E2-Related Factor 2TuberculosisAnimalsAntigen PresentationCD4-Positive T-LymphocytesImmunity, InnateInterferon-gammaLymphocyte ActivationMiceMice, Inbred C57BLHistocompatibility Antigens Class IIInterferon-gammaNfe2l2 protein, mouseNF-E2-Related Factor 2alveolar macrophagesantigen presentationCD4(+) T cellsCP: immunologyCP: microbiologyinnate-adaptive crosstalkinnate immunityMHC IIMycobacterium tuberculosismyeloid cellsNRF2

Identifiers

PMID42241288
PMCPMC13426489

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.