Evidence map›Paper›PMID 42241286›Full record

ArticleCell reports2026

Aging restricts maturation of CXCL13

Nathan A Bracey, Casey Beppler, Tatjana Bilich, Adrienne H Long, Elsa Sola, Aviv Barak, Timothy J Few-Cooper, Azam Mohsin, Vishnu Shankar, Vamsee Mallajosyula and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Nathan A BraceyDepartment of Medicine, Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB T2N 1N4, Canada; Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94304, USA.
Casey BepplerInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94304, USA.
Tatjana BilichInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94304, USA.
Adrienne H LongInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94304, USA; Department of Pediatrics, Division of Hematology and Oncology, Stanford University, Stanford, CA 94304, USA.
Elsa SolaInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94304, USA.
Aviv BarakBruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.
Timothy J Few-CooperBruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.
Azam MohsinInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94304, USA.
Vishnu ShankarInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94304, USA.
Vamsee MallajosyulaInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94304, USA.
Lilit KamalyanInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94304, USA.
Robson CapassoDivision of Sleep Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94304, USA.
Shai S Shen-OrrBruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 3200003, Israel.
Mark M DavisInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94304, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94304, USA. Electronic address: mmdavis@stanford.edu.

Funding

CXCL13 as an aging-associated defect in memory T cell homeostasisF32AI186256 · NIAID · STANFORD UNIVERSITY · PI Casey Beppler · 2024 to 2026
$193k
NIAID NIH HHS F32 AI186256
6 · The paper itself

Abstract

A decline in specific antibody responses is a hallmark of human aging, yet the differential contributions of B and T lymphocytes remain unclear. CXCL13 is a chemokine that shapes germinal center (GC) organization, but the regulation of human-specific CXCL13

Indexed as

AgingChemokine CXCL13T Follicular Helper CellsT-Lymphocytes, Helper-InducerAdultAgedB-LymphocytesCell DifferentiationFemaleGerminal CenterHumansMaleMiddle AgedPalatine TonsilYoung AdultChemokine CXCL13CXCL13 protein, humanagingCP: immunologyCXCL13gene regulationhuman immunologymaturationTfh cells

Identifiers

PMID42241286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.