Evidence map›Paper›PMID 42241279›Full record

ArticleCell reports2026

Spatio-molecular gene expression reflects dorsal anterior cingulate cortex structure and function in the human brain.

Kinnary Shah, Michael S Totty, Svitlana V Bach, Madeline R Valentine, Atharv Chandra, Haya A AlGrain, Heena R Divecha, Ryan A Miller, Felix Rene M Siewe, Sang Ho Kwon and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Kinnary ShahDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Michael S TottyDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Svitlana V BachLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Madeline R ValentineLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Atharv ChandraLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Haya A AlGrainLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Heena R DivechaLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Ryan A MillerLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Felix Rene M SieweLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Sang Ho KwonLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA; Biochemistry, Cellular, and Molecular Biology Graduate Program, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Ishbel Del Rosario AlviaLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Anthony D RamnauthLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Madhavi TippaniLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Sanjana TyagiLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Joel E KleinmanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Leonardo Collado-TorresDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA.
Shizhong HanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Genetic Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Thomas M HydeLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Stephanie C PageLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Kristen R MaynardLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Stephanie C HicksDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Center for Computational Biology, Johns Hopkins University, Baltimore, MD, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Malone Center for Engineering in Healthcare, Johns Hopkins University, Baltimore, MD, USA. Electronic address: shicks19@jhu.edu.
Keri MartinowichLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA; Johns Hopkins Kavli Neuroscience Discovery Institute, Baltimore, MD, USA. Electronic address: keri.martinowich@libd.org.

Funding

Registration of spatial gene expression in key nodes of reward-related circuitry in the human brainR01DA053581 · NIDA · LIEBER INSTITUTE, INC. · PI MARTINOWICH, KERI · 2021 to 2025
$3.7M
Neural substrates of extinction deficits in pathological fearF32MH135620 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Michael Totty · 2023 to 2026
$224k
IMPLICIT AND EXPLICIT MEMORY FOR FACES IN SOCIAL PHOBIAF31MH013006 · NIMH · TEMPLE UNIVERSITY · PI COLES, MEREDITH ELLEN · 2001 to 2002
$26k
NIDA NIH HHS R01 DA053581NIMH NIH HHS F31 MH013006NIMH NIH HHS F32 MH135620
6 · The paper itself

Abstract

The human brain's dorsal anterior cingulate cortex (dACC) is critical in cognitive control, specifically reward processing and conflict monitoring, and regulates fear and pain expression. The dACC is evolutionarily older than more recently specialized neocortical areas, such as the dorsolateral prefrontal cortex (dlPFC). Its evolutionary specializations, including agranularity and presence of von Economo neurons (VENs) are linked to its unique roles in cognitive and emotional processing. We generated paired spatially resolved transcriptomics (SRT) and single-nucleus RNA-sequencing (snRNA-seq) data in ten adult neurotypical donors to define cell types and spatial domains. We used non-negative matrix factorization to project gene expression patterns from the snRNA-seq data onto the SRT data to infer spatial localization. Utilizing publicly available resources, we explored spatial topography, enrichment of disease risk, and connectivity of spatially localized cell types, including VENs. Leveraging dlPFC snRNA-seq and SRT data from the same donors, we compared laminar and molecular specialization between the regions.

Indexed as

Gyrus CinguliAdultFemaleHumansMaleNeuronsSpatial TranscriptomicsTranscriptomeCP: molecular biologyCP: neurosciencedorsal anterior cingulate cortexpostmortem human brainsingle-nucleus RNA-sequencingspatially resolved transcriptomics

Identifiers

PMID42241279
PMCPMC13359017

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.