Evidence map›Paper›PMID 42241274›Full record

ArticleDrug delivery2026

Low-intensity pulsed ultrasound combined with microbubbles enhances amphotericin B delivery across the blood-brain barrier for improved therapy of cryptococcal meningitis.

Junyu Liu, Zhengtu Li, Dongcheng Li, Jia Liu, Yutian Su, Yifei Leng, Yongming Li, Li Xu, Lan Sun, Xiaohong Su and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Junyu LiuDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhengtu LiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Dongcheng LiDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Jia LiuDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yutian SuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yifei LengDepartment of Medical Ultrasound, Laboratory of Novel Optoacoustic (Ultrasonic) imaging, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yongming LiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Li XuDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Lan SunState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaohong SuDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xiaotong LiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Changyong TangDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Ying JiangDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xintao ShuaiNanomedicine Research Center, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Fuhua PengDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cryptococcal meningitis (CM), a life-threatening fungal infection of the central nervous system, faces therapeutic challenges due to poor blood‒brain barrier (BBB) penetration of amphotericin B. This study investigates the efficacy of low-intensity pulsed ultrasound (LIPUS) combined with microbubbles in enhancing BBB permeability and improving prognosis in a murine CM model. Our findings suggest that LIPUS combined with microbubbles treatment significantly increased BBB permeability, leading to elevated cerebral concentrations of amphotericin B and improved fungicidal activity against

Indexed as

Amphotericin BAntifungal AgentsBlood-Brain BarrierMeningitis, CryptococcalMicrobubblesAnimalsCryptococcus neoformansDisease Models, AnimalDrug Delivery SystemsMaleMicePermeabilityUltrasonic WavesVascular Endothelial Growth Factor AAmphotericin BAntifungal AgentsVascular Endothelial Growth Factor AAmphotericin Bblood–brain barriercryptococcal meningitislow-intensity pulsed ultrasoundmicrobubbles

Identifiers

PMID42241274
PMCPMC13237798

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.