Evidence map›Paper›PMID 42241252›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Artificial Transmembrane Channels for Selective Ascorbic Acid Transport and Bioorthogonal Signal Transduction.

Linlin Shi, Jingjing Ma, Linshuang Wang, Lingyu Zhao, Wen Zhao, Jianlei Li, Nan Lv, Xiaoyu Chang, Pengyang Xin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linlin ShiState Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, School of Pharmaceutical Sciences, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, China.
Jingjing MaState Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, School of Pharmaceutical Sciences, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, China.
Linshuang WangState Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, School of Pharmaceutical Sciences, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, China.
Lingyu ZhaoState Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, School of Pharmaceutical Sciences, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, China.
Wen ZhaoState Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, School of Pharmaceutical Sciences, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, China.
Jianlei LiState Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, School of Pharmaceutical Sciences, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, China.
Nan LvState Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, School of Pharmaceutical Sciences, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, China.
Xiaoyu ChangSchool of Pharmaceutical Sciences, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, Zhengzhou University, Zhengzhou, China.
Pengyang XinState Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, School of Pharmaceutical Sciences, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, China.ORCID 0000-0003-4947-7953

Funding

Central Plains Scholars and Scientists Studio Fund 2018002Henan Normal University Research Foundation for the Doctoral Program QD2024004National Natural Science Foundation of China 22271079National Natural Science Foundation of China 22571073National Natural Science Foundation of China 82130103Research Project from Pingyuan Laboratory 2023PY-ZZ-0201the Henan Key Laboratory of Organic Functional Molecules and Drug Innovation
6 · The paper itself

Abstract

Ascorbic acid (AA), an essential bioactive molecule, plays a pivotal part in maintaining physiological functions in cells and organisms, and its intracellular homeostasis is regulated by specific natural transporter proteins. Here we report a class of artificial transmembrane channels constructed from discrete covalent organic nanotubes that mediate the selective transmembrane transport of AA. X-ray structural analysis and vesicle-based fluorescence assays confirmed that these molecules adopt a rigid tubular architecture with a near-nanometer pore size, enabling their insertion into lipid bilayers to form stable transmembrane channels that mediate efficient AA transport. Importantly, AA transport mediated by these molecules can initiate bioorthogonal reactions, thereby converting an external chemical stimulus into a fluorescent signal within a biomimetic system.

Indexed as

Ascorbic AcidSignal TransductionBiological TransportLipid BilayersModels, MolecularNanotubesAscorbic AcidLipid Bilayersartificial channelsascorbic acidcyclodextrinssupramolecular chemistrytransmembrane transport

Identifiers

PMID42241252
PMCPMC13411411

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.