Evidence map›Paper›PMID 42241111›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Virus-induced transgene- and tissue culture-free heritable genome editing in tomato.

Ye Liu, Trevor Weiss, Jinhee Lee, Jessica Powell, Shi Ying Charlize Choo, Elnaz Roshannai, Maris Kamalu, Jasmine Amerasekera, Suhua Feng, Steven E Jacobsen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Virus-induced transgene- and tissue culture-free heritable genome editing in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ye LiuDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Trevor WeissDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Jinhee LeeDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Jessica PowellDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Shi Ying Charlize ChooDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Elnaz RoshannaiDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Maris KamaluDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Jasmine AmerasekeraDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Suhua FengDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.
Steven E JacobsenDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095.

Funding

NSF (NSF) 2334027
6 · The paper itself

Abstract

Genome editing has emerged as a powerful tool for genome manipulation and trait improvement in crops. However, most commonly used approaches rely on tissue culture and transgenic materials, which are time-consuming, labor-intensive, and often strongly genotype-dependent. Here, we developed a Tobacco rattle virus (TRV)-based system to deliver the compact ISYmu1 TnpB endonuclease, coupled with in planta shoot regeneration, to achieve somatic and heritable genome editing across different tomato cultivars without tissue culture. By targeting

Indexed as

Gene EditingGenome, PlantSolanum lycopersicumTransgenesFruitPlant ProteinsPlants, Genetically ModifiedPlant VirusesTissue Culture TechniquesPlant Proteinscompact TnpB endonucleaseenlarged tomato fruitheritable genome editingtransgene- and tissue culture-freevirus-induced gene editing

Identifiers

PMID42241111
PMCPMC13250589

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.