Evidence map›Paper›PMID 42240957›Full record

ArticleDigestive diseases and sciences2026

Functional and Anatomical Significance of Patulous Anus.

Leila Neshatian, Mohamad I Itani, Ofer Fass, George Triadafilopoulos, Vipul Sheth, Brooke Gurland

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Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Leila NeshatianDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, 430 Broadway St, Pav C 3rd Floor, GI Suite, Stanford, Redwood City, CA, 94063, USA. lneshati@stanford.edu.
Mohamad I ItaniDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, 430 Broadway St, Pav C 3rd Floor, GI Suite, Stanford, Redwood City, CA, 94063, USA.
Ofer FassDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, 430 Broadway St, Pav C 3rd Floor, GI Suite, Stanford, Redwood City, CA, 94063, USA.
George TriadafilopoulosDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, 430 Broadway St, Pav C 3rd Floor, GI Suite, Stanford, Redwood City, CA, 94063, USA.
Vipul ShethDepartment of Radiology, Stanford University School of Medicine, Stanford, CA, USA.
Brooke GurlandDepartment of Surgery, Stanford University, Stanford, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA patulous anus is often associated with prior anal sphincter injury and fecal incontinence (FI). We aimed to understand the clinical and functional significance of a patulous anus as identified on MRI defecography (MRD).

methodsWe conducted a retrospective review of the clinical characteristics, high-definition anorectal manometry, MRD, and symptom severity scores from a prospectively maintained registry of patients with or without patulous anus.

resultsOf the 161 patients (86.3% women), who presented with various anorectal symptoms, 47 (29%) exhibited a patulous anus. Ninety-five percent of patients with a patulous anus were women (p = 0.018), older (66 ± 12.7 vs. 56 ± 15.1 y, p = 0.0003), and had a history of pelvic surgery (39% vs. 22%, p = 0.038). Patients with a patulous anus were more likely to report FI with higher Wexner scores (p < 0.05), associated with a shorter anal high-pressure zone, reduced resting tone and squeeze pressures (p < 0.01), independent of age, gender, and previous surgeries. MRD revealed higher Oxford grades of rectal intussusception (p < 0.0001), longer levator hiatus length (p = 0.002), greater perineal descent (p = 0.006), and a wider anorectal angle at rest (p < 0.001). After adjusting for age, gender, and history of previous pelvic surgeries, such differences remained significant. Stepwise logistic regression identified higher Oxford grade, lower resting tone, and wider anorectal angle at rest as independent predictors of a patulous anus.

conclusionA patulous anus on MRD indicates clinically important underlying anorectal anatomical and functional abnormalities and warrants screening for FI and/or advanced rectal intussusception.

Indexed as

Anal CanalAnus DiseasesFecal IncontinenceAdultDefecographyFemaleHumansMagnetic Resonance ImagingMaleManometryMiddle AgedRetrospective StudiesAnorectal manometryFecal incontinenceMRI defecographyPatulous anusRectal intussusception

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.