Evidence map›Paper›PMID 42240936›Full record

ArticleJournal of cancer survivorship : research and practice2026

Trajectories of patient-reported outcomes among diverse cancer patients in ambulatory oncology clinics.

Akina Natori, Blanca Silvia Noriega Esquives, Vandana D Sookdeo, Rui Gong, Jessica MacIntyre, Patricia I Moreno, Carmen Calfa, Tracy E Crane, Matthew Schlumbrecht, Frank J Penedo

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Article in Journal of cancer survivorship : research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Akina NatoriDivision of Medical Oncology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Blanca Silvia Noriega EsquivesSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Vandana D SookdeoSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Rui GongDivision of Medical Oncology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Jessica MacIntyreSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Patricia I MorenoDepartment of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL, USA.
Carmen CalfaDivision of Medical Oncology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Tracy E CraneDivision of Medical Oncology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, USA.
Matthew SchlumbrechtSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Frank J PenedoSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA. fpenedo@miami.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTracking patient-reported outcomes (PROs) offers critical insights into cancer survivors' symptoms and health-related quality of life (HRQOL). This study evaluated longitudinal trajectories of PROs across cancer types and identified factors associated with symptom burden and HRQOL.

methodsWe conducted a retrospective longitudinal observational study of 6939 cancer survivors (breast, prostate, lung, head and neck (H&N), gastrointestinal (GI), gynecological (GYN), and hematological malignancies) in ambulatory oncology clinics. All cancer survivors completed electronic health record-integrated PRO assessments measuring anxiety, depression, pain interference, fatigue, and physical function, and HRQOL. Linear mixed-effect models evaluated difference in PRO level and change over time by cancer types, adjusting for sociodemographic and clinical covariates.

resultsMeaningful differences in overall symptom burden were observed across cancer types. Survivors with GYN cancers reported consistently higher anxiety, pain interference, fatigue, and poorer physical function, whereas prostate cancer survivors reported lowest symptom burden and highest HRQOL. Hematologic malignancy survivors improved in physical function over time compared to prostate cancer survivors. Chemotherapy and surgery were associated with greater pain interference, fatigue, reduced physical function, and lower HRQOL. Greater comorbidity burden and being unpartnered were associated with worse PRO.

conclusionsPRO trajectories varied by cancer types and patient characteristics, underscoring the need for tailored, cancer-specific survivorship care strategies. IMPLICATIONS FOR CANCER SURVIVORS: Routine, EHR-integrated PRO monitoring can identify survivors at risk for persistent symptom burden and support timely, individualized interventions to improve long-term HRQOL.

Indexed as

Cancer survivorsHealth-related quality of lifeLongitudinal studiesPatient-reported outcome measures

Identifiers

PMID42240936

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.