Evidence map›Paper›PMID 42240902›Full record

ArticleVeterinary research communications2026

Effects of dietary supplementation with chitosan nanogel on biochemical, antioxidant traits, and resistance to Aeromonas sobria infection, in Cyprinus carpio fingerlings.

Hanan M Alharbi, Heba H Mahboub, Yasmine A Mansour, Rasha M M Ezz-Eldin, Sherif M Shawky, Sahar H Orabi, Sameh H Ismail, Tarek Khamis, Shaimaa A A Ahmed

Abstract read
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Article in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hanan M AlharbiDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia.
Heba H MahboubDepartment of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt. hhhmb@yahoo.com.
Yasmine A MansourDepartment of cytology and histology, Faculty of Veterinary Medicine, Cairo university, Giza, Egypt.
Rasha M M Ezz-EldinDepartment of Biochemistry and Molecular Biology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt.
Sherif M ShawkyDepartment of Physiology, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Menofia, 32897, Egypt.
Sahar H OrabiDepartment of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Menofia, 32897, Egypt.
Sameh H IsmailFaculty of Nanotechnology for Postgraduate Studies, Cairo University, PO Box 12588, Sheikh Zayed Branch Campus, Sheikh Zayed City, Giza, Egypt.
Tarek KhamisDepartment of Pharmacology, Faculty of Veterinary Medicine, Zagazig University, PO Box 44511, Zagazig, Sharkia, Egypt.
Shaimaa A A AhmedDepartment of Aquatic Animal Medicine, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44511, Egypt. shaimaakarim2020@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was designed to evaluate the modulating effect of dietary chitosan nanogel (CHNG) on antioxidant status and hepato-renal function in Cyprinus carpio. Fish were allocated into 4 groups, each group consisted of 45 fish in triplicates, where each replicate was represented by an aquarium (15 fish/ aquarium). The prophylactic feeding trial lasted for sixty days, where fish were placed on either control, CHNG0.5%, 1% or 1.5%-supplemented diet, then, growth performance was assessed and serum samples was collected for biochemical and antioxidant assessments. Afterwards, fish in the four experimental groups were challenged with Aeromonas sobria,where clinical signs and mortalities were monitored over the fourteen-day challenge period. Then, tissue sampling was performed in order to assess the histopathological outcomes and hepatic gene expression in different groups. The outcomes revealed enhancement of hepato-renal function including ALT, AST, ALP, creatinine, and urea in CHNG-supplemented fish. The control group revealed a remarkable increase in tissue malondialdehyde (MDA) levels that was inhibited by CHNG supplementation in a level-related pattern. The activities of reduced glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) in liver tissue were significantly elevated in a dose-dependent manner in CHNG-supplemented groups. After A. sobria challenge, the hepatic gene expression showed that dietary supplementation with CHNG induced significant down-regulation of apoptosis-related signaling (cERK-1, JNK, P38, and Casp-8) compared with the control group which was challenged with A. sobria and received a basal diet devoid of CHNG. Interestingly, histopathological investigations showed a notable improvement in CHNG-fortified groups relative to the challenged group. Taken together, CHNG-dietary intervention is a potential candidate for enhancing the resistance to A. sobria infection in Cyprinus carpio.

Indexed as

AntioxidantsCarpsChitosanDisease ResistanceFish DiseasesGram-Negative Bacterial InfectionsAeromonasAnimal FeedAnimalsDietDietary SupplementsAntioxidantsChitosanAeromonas sobriaAntioxidant traitsChitosan nanogelCyprinus carpioFingerlingsGene expression

Identifiers

PMID42240902

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.