ArticleIntensive care medicine experimental2026
Chest compression synchronized ventilation versus chest compression superimposed by sustained inflation in asphyxiated newborn piglets: a randomized animal trial.
Article in Intensive care medicine experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundGuidelines on neonatal resuscitation recommend 90 chest compressions (CCs) and 30 ventilations (3:1 C:V) per minute in newborns. We have described an alternative resuscitation strategy where CCs are superimposed with sustained inflation (CC + SI), which allows for passive ventilation during compression. A more recent strategy is CCs with synchronized ventilation (CCSV), in which a ventilator flow sensor recognizes airflow during the downward phase of compression and thereby triggers an inflation. No study has compared CCSV with CC + SI in an asphyxiated newborn piglet model. Newborn piglets (n = 8/group) were anesthetized, intubated, instrumented, and exposed to 45 min of normocapnic hypoxia, followed by asphyxia and asystolic cardiac arrest. Piglets were randomized to CCSV or CC + SI. Hemodynamic and respiratory parameters were continuously measured.
resultsSixteen neonatal mixed-breed piglets (1-3 days of age, weighing 1.7-2.8 kg) were randomized to CCSV or CC + SI. Median (IQR) time to ROSC was 68 (50-125) s with CCSV and 71 (60-178) s with CC + SI (p = 0.537). The rate of ROSC with CCSV compared to CC + SI was 6/8 (75%) vs. 5/8 (63%), respectively, p = 1.000. CCSV had significantly higher peak inflation pressure (45 vs. 36 cmH
conclusionsUse of CCSV did not result in a faster time to ROSC compared to CC + SI, and survival rates and physiological stability did not differ significantly.
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