ArticleClinical oral investigations2026
Simultaneous implant placement with guided bone regeneration for horizontal ridge augmentation using a 3D-preformed resorbable PLGA membrane: A prospective single-arm clinical study.
Article in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- HAp/PLGA/Chitosan Scaffolds Fabricated by Freeze-Drying and 3D Printing for Bone Regeneration: In Vitro Evaluation and Finite Element Analysis.Biomimetics (Basel, Switzerland) · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to evaluate the clinical effectiveness and safety of guided bone regeneration (GBR) using a three-dimensional preformed resorbable Polylactic-co-glycolic acid membrane (3D-PRPM) with simultaneous implant placement. MATERIALS AND
methodsTwenty patients (21 sites) with localized ridge defects were treated using implants placed concurrently with GBR using a 3D-PRPM. Cone-beam computed tomography scans were taken preoperatively, immediately postoperatively, and at 5 months. Horizontal bone augmentation (BA), hard tissue gain (HG), bone resorption (BR), and hard tissue gain rate (HGR) were assessed. Changes beyond the original bony envelope were evaluated. Statistical analyses included the Wilcoxon signed-rank and Friedman tests.
resultsMean BA was 2.99 ± 1.15 mm, and mean HG at 5 months was 2.64 ± 1.10 mm. Mean BR was 0.35 ± 0.23 mm, and mean HGR was 87.2% ± 8.2%. Envelope analysis confirmed a significant increase after augmentation with partial reduction during healing; however, ridge dimensions at 5 months remained significantly greater than baseline (P < 0.001). No membrane exposure, infection, or wound dehiscence occurred.
conclusion3D-PRPM enabled predictable horizontal ridge augmentation with excellent volumetric stability and favorable short-term safety. CLINICAL RELEVANCE: A 3D-PRPM may provide a stable, fixation-free resorbable barrier for horizontal ridge augmentation, potentially simplifying GBR procedures and reducing the need for secondary removal.
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