ArticleClinical rheumatology2026
Assessment of disease severity in systemic sclerosis-associated interstitial lung disease using a modified lung ultrasound score: correlation with pulmonary function, HRCT, and clinical scores, and evaluation of diagnostic efficacy.
Article in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundThis study aimed to evaluate the utility of a modified lung ultrasound (LUS) score in assessing the severity of systemic sclerosis (SSc)-associated interstitial lung disease (ILD) and to analyze its correlations with pulmonary function tests, high-resolution computed tomography (HRCT) scores, and clinical severity assessments.
methodsA total of 53 SSc patients and 36 healthy controls were enrolled. Baseline characteristics, pulmonary function parameters, HRCT Warrick scores, Medsger lung severity scores, and lung ultrasound parameters (modified LUS score and Buda score) were collected. Correlation analysis and multiple linear regression were used to examine the relationship between ultrasound scores and other indicators. Diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis.
resultsThe modified LUS score was significantly higher in the SSc group than in the healthy controls (51.0 vs. 1.0, p < 0.001) and exhibited an increasing trend with higher Medsger scores. It showed a strong positive correlation with the HRCT Warrick score (r = 0.95, p < 0.001) and strong negative correlations with relevant pulmonary function parameters. Multiple regression analysis identified the modified LUS score, SSc subtype, anti-Scl-70 antibody positivity, and body mass index as independent factors influencing the Medsger lung score (all p < 0.05). ROC analysis demonstrated that the modified LUS score achieved areas under the curve (AUC) of 0.980 and 0.973 for diagnosing moderate-to-severe (Medsger ≥ 2) and severe (Medsger ≥ 3) lung respectively, demonstrating favorable sensitivity and specificity compared to the Buda score.
conclusionThe modified LUS score strongly correlates with radiological, functional, and clinical severity in SSc-ILD, indicating its potential as an effective, non-invasive tool for assessing disease severity. Key Points • The modified LUS score strongly correlates with HRCT, pulmonary function, and clinical severity in SSc-ILD. • It is an independent predictor of disease severity and outperforms the traditional Buda score. • The modified LUS score enables effective non-invasive stratification of moderate-to-severe and severe disease.
Indexed as
Identifiers
42240787What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.