Trial reportClinical oral investigations2026
Hydroxyapatite composite sodium hyaluronate for alveolar ridge preservation: a prospective, randomized, parallel-controlled, single-blind, non-inferiority multicenter clinical trial.
Trial report in Clinical oral investigations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
objectivesEvaluate the efficacy and safety of the combination of sodium hyaluronate and hydroxyapatite for alveolar ridge preservation in fresh extraction sockets with bone defects. MATERIALS AND
methodsA total of 200 patients, who required tooth extraction due to dental, periodontal, or periapical diseases, were enrolled in five dental clinic centers across China. Alveolar bone defects were identified, and bone grafting was indicated for defects with a depth of ≥ 3 mm on one or more sides of the affected tooth's bone wall, as measured by Cone Beam CT (CBCT). Participants were randomly and equally assigned to either the experimental group, which received hydroxyapatite composite sodium hyaluronate (HAp/HA) implants in the fresh tooth extraction socket, or the control group, which was given a reference bone substitute. Postoperative follow-up assessments were conducted for up to 24 weeks. Changes in alveolar ridge height and width at the implantation site were evaluated blindly using CBCT. Simultaneously, the local healing condition and systemic safety profiles were evaluated.
resultsHAp/HA exhibits superior adhesion, facilitating easier filling and shaping during dental procedures in comparison to control material. Postoperative CBCT images, performed right after the operation and at the 24-week follow-up, showed a minimal alteration in alveolar ridge height (-0.33 ± 1.74 mm) and width (-0.60 ± 1.95 mm) subsequent to HAp/HA implantation, indicating no significant variance when compared to the control material. At the 24-week follow-up, the osseointegration of the implanted material with the alveolar bone was scored using a 3-grade system, with the HAp/HA group showing slightly higher average scores than the control group, though not statistically significant. No post-operative infections or material rejections were observed in either group.
conclusionsHAp/HA can be an effective and safe material for alveolar ridge preservation in tooth extraction sockets with defects. CLINICAL RELEVANCE: Hydroxyapatite composite sodium hyaluronate possess clinical value for alveolar ridge preservation.
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