ArticleMolecular biology reports2026
Growth factor betacellulin can stimulate human granulosa cell functions and promote gonadotropin actions.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBetacellulin (BTC), an EGF-family growth factor expressed in granulosa cells, is implicated in ovarian regulation; however, its interactions with gonadotropins in humans remain unclear.
objectiveTo determine how BTC alone or combined with follicle-stimulating hormone (FSH) or luteinizing hormone (LH) affects human granulosa cell viability, proliferation, apoptosis, and progesterone secretion.
methodsHuman granulosa cells were treated with BTC (1-100 ng/ml) ± FSH or LH (100 ng/ml). Viability was measured by Trypan blue exclusion; proliferation and apoptosis by immunocytochemistry; and progesterone by ELISA.
resultsBTC dose-dependently increased viability, proliferation (cyclin B1, PCNA), and progesterone secretion, while reducing apoptosis (bax, caspase-3). Both FSH and LH enhanced all BTC effects, further increasing proliferation, viability, progesterone output, and anti-apoptotic activity.
conclusionBTC may regulate human granulosa cell function, acting in concert with gonadotropins to modulate viability, proliferation, apoptosis, and steroidogenesis, highlighting its role as a paracrine mediator in ovarian physiology.
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