ArticleArchives of women's mental health2026
Global, regional, and national burden of depression among women of childbearing age from 1990 to 2021: insights from the Global Burden of Disease Study 2021.
Article in Archives of women's mental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeDepression is a common mental disorder, particularly among women of childbearing age (WCBA). There is a lack of comprehensive epidemiological analysis on the longitudinal trends and changing patterns of depression in WCBA.
methodsThe study utilized data obtained from the Global Burden of Disease (GBD) 2021 database to analyze incidence, prevalence, and years lived with disability (YLDs) of depression among WCBA across regions, age groups, and sociodemographic index (SDI). We also examined temporal trends, driving factors, age patterns, and projections up to 2035.
resultsGlobally, from 1990 to 2021, the incidence rate increased by 17.65% (95% UI, 13.51 to 21.84), prevalence rate by 15.00% (95% UI, 11.53 to 18.39), and YLDs rate by 16.03% (95% UI, 12.39 to 19.86). Among the five SDI regions, the highest EAPCs were observed in the high SDI regions for incidence rate (0.49; 95% UI, 0.26 to 0.72), prevalence rate (0.33; 95% UI,0.15 to0.50), and YLDs rate (0.40; 95% CI, 0.20 to 0.60). Regionally, a U-shaped association was found between the SDI and rate of incidence, prevalence, and YLDs. Nationally, Greenland reported the highest rates of three indicators in 2021, whereas Mexico exhibited the largest growth over time. This study found that the 15-19 age group showed a particularly severe new burden of depression among WCBA in 2021, especially in high SDI. The highest burden of depression among WCBA was reported in the older age groups such as 40-44 and 45-49 age groups. Population growth and epidemiological change were the primary drivers of this change except in low SDI which aging was the primary driver. Our study predictions suggested that the burden of depression among WCBA will continue to grow in the future.
conclusionsOverall, the burden of depression among WCBA has significantly increased globally over the past 32 years, particularly in high SDI regions and among the 15-19 age group. The findings underscore the need for tailored interventions to control the projected rise burden of depression among WCBA.
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