Evidence map›Paper›PMID 42240663›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

DDIT4 silencing attenuates sevoflurane-induced ferroptosis via the mTOR pathway in neuronal cells.

Shijian Yu, Minxuan Xi, Jiawei Chen, Hao Yang, Zhihong Xu

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shijian Yu *Department of Anesthesiology, Jing'an District Centre Hospital of Shanghai, Fudan University, No. 259 Xikang Road, Shanghai, 200040, China.
Minxuan Xi *Department of Anesthesiology, Jing'an District Centre Hospital of Shanghai, Fudan University, No. 259 Xikang Road, Shanghai, 200040, China.
Jiawei ChenDepartment of Anesthesiology, Jing'an District Centre Hospital of Shanghai, Fudan University, No. 259 Xikang Road, Shanghai, 200040, China.
Hao YangDepartment of Intensive Care Medicine, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, 200040, China. 15921316221@163.com.
Zhihong XuDepartment of Intensive Care Medicine, Jing'an District Centre Hospital of Shanghai, Fudan University, Shanghai, 200040, China. 18017312700@163.com.

Funding

Jing'an District Municipal Health Commission Foundation for Key Developing Disciplines 2024BR01
6 · The paper itself

Abstract

DNA damage-inducible transcript 4 (DDIT4) participates in neuronal cell ferroptosis and can be upregulated by sevoflurane (Sev). This study aimed to explore whether silent DDIT4 can improve Sev-induced neuronal cell ferroptosis and its potential mechanism. HT22 and SH‑SY5Y cells were transfected with siDDIT4 and exposed to Sev with or without the mammalian target of rapamycin (mTOR) inhibitor rapamycin. In both HT22 and SH-SY5Y cells, Sev exposure increased DDIT4, promoted ferroptosis, and inhibited the mTOR pathway (all P < 0.05). DDIT4 knockdown improved HT22 and SH-SY5Y cell viability (both P < 0.05), reduced reactive oxygen species (ROS) (both P < 0.05), malondialdehyde (MDA) (both P < 0.05), and Fe

Indexed as

Anesthetics, InhalationFerroptosisNeuronsSevofluraneTOR Serine-Threonine KinasesTranscription FactorsAnimalsCell LineCell Line, TumorCell SurvivalGene SilencingHumansMiceReactive Oxygen SpeciesSignal TransductionAnesthetics, InhalationDDIT4 protein, humanDdit4 protein, mouseMTOR protein, humanmTOR protein, mouseReactive Oxygen SpeciesSevofluraneTOR Serine-Threonine KinasesTranscription FactorsDDIT4FerroptosisMTOR pathwayNeuronal cellsSevoflurane

Identifiers

PMID42240663

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.