ArticleJournal of the science of food and agriculture2026
Ultrasound-assisted enzymatic extraction of citrus pomace yields dietary fiber-rich extract with skin-protective effects.
Article in Journal of the science of food and agriculture, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCitrus pomace is an abundant byproduct of citrus juice processing and represents a sustainable source of dietary fiber and bioactive polysaccharides. The present study aimed to valorize citrus pomace through ultrasound-assisted enzymatic extraction (UAEE) and to evaluate the protective effects of the resulting extract obtained by Celluclast® treatment with ultrasound pretreatment (CCU) against particulate matter (PM)-induced skin damage.
resultsUAEE markedly improved the extraction yield of citrus pomace extract, with CCU showing a higher yield (55.17%) than distilled water extraction (15.67%) and Celluclast® extraction without ultrasound pretreatment (54.00%). CCU also showed the highest dietary fiber recovery based on extraction yield. In PM-stimulated HaCaT keratinocytes, CCU increased cell viability from 75.26% to 94.12% and reduced intracellular reactive oxygen species production in a concentration-dependent manner. CCU further suppressed PM-induced pro-inflammatory responses by reducing tumor necrosis factor-α, interleukin-1β and interleukin-6 levels, as well as inducible nitric oxide synthase and cyclooxygenase-2 protein expression. In addition, CCU restored the expression of skin barrier-and hydration-related proteins, including filaggrin, loricrin, involucrin and hyaluronic acid synthase 1. In vivo, oral administration of CCU also alleviated PM-induced inflammation and water loss in mouse skin.
conclusionThese findings demonstrate that UAEE is an effective approach for converting citrus pomace into a dietary fiber-rich functional extract with anti-inflammatory and skin barrier-protective properties. CCU may therefore serve as a value-added ingredient for nutraceutical or skin-health-related functional applications. © 2026 Society of Chemical Industry.
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