Evidence map›Paper›PMID 42240529›Full record

ArticleJACC. Advances2026

Female Sex Is Not a Uniform Risk Factor in Atrial Fibrillation.

Cecile McGarvey, Emma Lunn, Yishi Jia, Yara Menassa, Yingshuo Liu, Mayana Bsoul, Christian Massad, Maximillian Moersdorf, Alex El Darazi, Michel Abou Khalil and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Cecile McGarveyTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Emma LunnTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Yishi JiaTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Yara MenassaTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Yingshuo LiuTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Mayana BsoulTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Christian MassadTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Maximillian MoersdorfTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Alex El DaraziTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Michel Abou KhalilTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Mohammad M AtasiTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Carlo El KhouryTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Rodolfo Montiel QuinteroTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Omar KriediehTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Qussay MarashlyTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Nassir F MarroucheTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.
Amitabh C PandeyTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA. Electronic address: apandey@tulane.edu.
Han FengTulane Research Innovation for Arrhythmia Discovery, Tulane University School of Medicine, Department of Cardiology, New Orleans, Louisiana, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFemale sex is a part of the stroke risk stratification in atrial fibrillation (AF), although emerging evidence suggests it may function as a risk modifier rather than an independent risk factor.

objectivesThis study aimed to determine whether female sex is a risk factor or risk modifier for stroke in patients with AF.

methodsUsing TriNetX, nonvalvular AF patients were identified and stratified by sex and age (<65, 65-74, and ≥75 years). Female and male patients were propensity matched for comorbidities and anticoagulation. Analyses were conducted comparing male and female patients with no CHA

resultsIn patients without additional CHA

conclusionsFemale sex acts as a modest risk modifier for thromboembolic stroke. Increased risk is primarily observed in patients with greater comorbidity burden or advanced age (≥75 years).

Indexed as

arterial embolismatrial fibrillationfemalethromboembolic stroke

Identifiers

PMID42240529
PMCPMC13309320

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.