Evidence map›Paper›PMID 42240526›Full record

ReviewJournal of the American Dental Association (1939)2026

Driving emerging technology to clinical impact.

W Benton Swanson, David T Wu, Mutsumi Yoshida, Jeanne Ambruster, Charles S Sfeir, William R Wagner, David J Mooney, William V Giannobile, David H Kohn

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of the American Dental Association (1939), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

W Benton SwansonDepartment of Oral Medicine, Infection and Immunity, School of Dental Medicine, Harvard University, Boston, MA.
David T WuDepartment of Oral Medicine, Infection and Immunity, School of Dental Medicine, Harvard University, Boston, MA; John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA.
Mutsumi YoshidaDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI.
Jeanne AmbrusterThe Avenues Company, Flagstaff, AZ.
Charles S SfeirDepartment of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA.
William R WagnerMcGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA; Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA.
David J MooneyJohn A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA.
William V GiannobileDepartment of Oral Medicine, Infection and Immunity, School of Dental Medicine, Harvard University, Boston, MA.
David H KohnDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI. Electronic address: dhkohn@umich.edu.

Funding

Michigan-Pittsburgh-Wyss Regenerative Medicine Resource Center: Advancing Dental, Oral, and Craniofacial Regeneration to Clinical Trial InitiationU24DE029462 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GIANNOBILE, WILLIAM V, KOHN, DAVID H. · 2020 to 2024
$31.3M
Michigan-Pittsburgh-Wyss Resource Center: Supporting Regenerative Medicine in Dental, Oral and Craniofacial TechnologiesU24DE026915 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GIANNOBILE, WILLIAM V, KOHN, DAVID H. · 2017 to 2019
$11.7M
NIDCR NIH HHS U24 DE026915NIDCR NIH HHS U24 DE029462
6 · The paper itself

Abstract

backgroundDental, oral, and craniofacial regenerative medicine has benefitted from fundamental scientific discoveries, yet the resulting technologies and therapies do not always generate the anticipated clinical impact. Despite robust progress and substantial investment in biomaterials and tissue engineering, few breakthroughs have achieved widespread adoption in the clinical arena. TYPES OF STUDIES REVIEWED: The authors analyzed the translational bottlenecks, such as regulatory complexity, gaps in meaningful clinical evidence, and economic and cultural barriers, that have limited the impact of even US Food and Drug Administration-approved technologies.

resultsThe authors highlight successful strategies from the Translational Resource Center, emphasize the importance of milestone-driven development and early clinical and stakeholder input, and propose a right-to-left translational paradigm that frames clinical adoption as the ultimate goal from project inception. CONCLUSIONS AND PRACTICAL IMPLICATIONS: By means of advocating for clinical evidence and outcomes that resonate with both patients and providers, the authors outlined a new road map for bridging the gap between emerging technologies and clinical impact.

Indexed as

Regenerative MedicineTechnology, DentalTranslational Research, BiomedicalHumansTissue EngineeringUnited StatesUnited States Food and Drug Administrationclinical evidence generationclinical translationDental regenerative medicineFDA regulatory sciencepractice-based researchright-to-left paradigmtechnology adoptiontranslational research infrastructure

Identifiers

PMID42240526
PMCPMC13559091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.