Increased low-molecular-weight mucins in muco-obstructive airway disease limit

Caitlyn C Sebastian, RaNashia Boone, Susan E Birket, Megan R Kiedrowski

Abstract read

In one paragraph

Article in Infection and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Caitlyn C SebastianDivision of Pulmonary, Allergy and Critical Care, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0001-9845-3929

RaNashia BooneDivision of Pulmonary, Allergy and Critical Care, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

Susan E BirketDivision of Pulmonary, Allergy and Critical Care, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-6353-6596

Megan R KiedrowskiDivision of Pulmonary, Allergy and Critical Care, Department of Medicine, Heersink School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0003-4610-182X

Funding

The Role of Airway Mucus in Infection and InflammationR01HL153079 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BIRKET, SUSAN ELIZABETH · 2021 to 2025

$2.2M

Cystic Fibrosis Foundation DAVIS23R0Cystic Fibrosis Foundation KIEDRO24P0NHLBI NIH HHS R01 HL153079NHLBI NIH HHS R01HL153079

6 · The paper itself

Abstract

Muco-obstructive airway diseases result in an increase in mucus accumulation and a decrease in mucus clearance. MUC5B is the most abundant secreted mucin in the human airways, and MUC5B mucin strands dimerize to create the mucus mesh network in the healthy respiratory tract. In muco-obstructive airway diseases like cystic fibrosis (CF), immune cells and bacteria release enzymes that degrade MUC5B into smaller fragments that become entangled and compacted, contributing to pathogenesis. We utilized synthetic cystic fibrosis sputum media (SCFM) to examine how mucin polymers can impact

Indexed as

Cystic FibrosisMucinsStaphylococcal InfectionsStaphylococcus aureusBiofilmsHaemophilus influenzaeHumansMolecular WeightPseudomonas aeruginosaSputumMucinsaggregationbiofilmsmucinmuco-obstructive airway diseaseStaphylococcus aureus

Identifiers

PMID42240337

DOI10.1128/iai.00693-25

PMCPMC13367046

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.