Trial reportActa orthopaedica2026
Change in bone mineral density after cemented and uncemented knee arthroplasty with an asymmetrical tibial component: secondary analysis of a randomized study using dual-energy X-ray absorptiometry.
Trial report in Acta orthopaedica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03563131 (Tibial and Femoral Components Migration and Adaptive Bone Remodeling After Insertion of Persona® Total Knee Arthroplasty. A RCT Using RSA and DEXA Analysis for Evaluation of Uncemented With Trabecular Metal Surface vs. Cemented Fixation), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tibial and Femoral Components Migration and Adaptive Bone Remodeling After Insertion of Persona® Total Knee Arthroplasty. A RCT Using RSA and DEXA Analysis for Evaluation of Uncemented With Trabecular Metal Surface vs. Cemented Fixation
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeTotal knee arthroplasties (TKA) affect the mechanical loading of the knee joint and may be associated with changes in bone mineral density (BMD). We aimed to evaluate adaptive periprosthetic BMD after cemented and uncemented TKA.
methodsThis is a secondary report of an earlier published RCT. Patients receiving cemented (n = 31) or uncemented (n = 32) TKA were included in a randomized controlled trial (RCT) with a 1:1 allocation. BMD was measured using Dual-energy X-ray Absorptiometry (DEXA) at 1 week and 3, 6, 12, and 24 months postoperatively in 3 regions of interest (ROI) in the femur and tibia. Changes in BMD were assessed using a paired t-test, and between-groups differences using an unpaired t-test. Time-related changes were analyzed using ANOVA. The study was registered at clinicaltrials.gov (NCT03563131) before enrolment.
resultsFemoral components: Over 2 years, BMD in ROI I decreased by 33% in the uncemented group and 21% in the cemented group, with a between-group difference of 12.2 percentage points (95% confidence interval [CI] 5.3-19.1; significant). In ROI II, the decrease was 19% vs 13%, with a between-group difference of 6.1 percentage points (CI -1.2 to 13.5; not significant). In ROI III, decreases were 6% vs 7%, with a between-group difference of -0.6 percentage points (CI -4.3 to 3.3; not significant). Tibial components: Changes were small (-4.7 to 3.3%), with significant decreases only in ROI I in the cemented group over 24 months. No significant between-group differences were observed.
conclusionThe periprosthetic BMD after TKA decreased both around cemented and uncemented components, particularly in ROI I after using an uncemented femoral component, whereas the decrease under the tibial components was small and of uncertain clinical significans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.