ArticleJournal of clinical laboratory analysis2026
Duplex Recombinase Polymerase Amplification-Lateral Flow Assay for Rapid Visual Detection of Critical Antibiotic Resistance Genes in Escherichia coli and Klebsiella pneumoniae From Positive Blood Cultures.
Article in Journal of clinical laboratory analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundBloodstream infections (BSIs) caused by multidrug-resistant bacteria (MDR) are a leading cause of mortality and morbidity among hospitalized patients. Extended-Spectrum Beta-Lactamase (ESBL), carbapenem-resistant Enterobacterales (CRE), and colistin resistance are critically important antibiotic-resistant bacteria. The rapid identification of these critical antibiotic resistance genes from positive blood cultures is essential for accelerating the diagnostic turnaround time, enabling early therapy, and supporting effective antibiotic stewardship programs.
methodsRecombinase Polymerase Amplification (RPA) integrated with an in-house Lateral Flow Assay (LFA) for duplex detection of bla
resultsThe optimal primer concentrations of bla
conclusionThis developed duplex RPA-LFA assay is well-suited for rapid screening in positive blood cultures, providing a cost-effective tool for the treatment, surveillance, and control of MDR in critical infections.
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