ArticleCancer control : journal of the Moffitt Cancer Center
External Radiation Versus Internal Radiation for Patients With Advanced Gastroenteropancreatic Neuroendocrine Neoplasms: A Retrospective Cohort Study.
Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
IntroductionWhile surgical resection is a common treatment for gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs), it is frequently unsuitable for advanced cases. Radiation therapy is emerging as a viable alternative. This retrospective cohort study aimed to compare the long-term outcomes of external versus internal radiation in advanced GEP-NENs.MethodsAdvanced GEP-NENs patients diagnosed from 2000 to 2020 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was applied to mitigate selection bias. The Kaplan-Meier method and multivariate Cox proportional hazards models were utilized to evaluate overall survival (OS) and cancer-specific survival (CSS).ResultsA total of 758 patients were enrolled in the study, with 597 receiving external radiation and 161 receiving internal radiation. A higher percentage of older patients, with advanced grades, lymph node metastases, and larger tumors, received external radiation. Before PSM, the OS (
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