ArticleCurrent opinion in behavioral sciences2016
Role of striatal dopamine signaling in compulsive eating associated with obesity.
Article in Current opinion in behavioral sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice.International journal of molecular sciences · 2021Article
- Reward sensitivity deficits in a rat model of compulsive eating behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Prediction of future weight change with dopamine transporter in patients with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
As access to inexpensive energy-dense foods increases and lifestyles become ever more sedentary obesity levels have climbed. The mesoaccumbens dopamine system is essential to maintaining appropriate control over feeding and associated behaviors. Emerging evidence suggests that consumption of highly palatable energy-dense food profoundly impacts mesoaccumbens dopamine neurotransmission and downstream signaling cascades in cortical and limbic regions. Furthermore, it is increasingly clear that dysregulation of dopamine receptor function contributes to the emergence of compulsive food intake, which likely contributes to weight gain, development of obesity and difficulties losing weight. Understanding the nature of these perturbations in mesoaccumbens dopamine may reveal novel strategies for medications development to combat obesity and obesity-associated diseases.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.