ArticleFrontiers in oncology2026
Dependence of energy balance and hypothalamic neuropeptide gene expression on initial tumor load in mice.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Animal models of cancer anorexia/cachexia are instrumental in investigating the underlying mechanisms. However, even among reports on the same cancer model, experimental procedures can vary, hindering the comparisons between studies. Methods: To determine the impact of the number of implanted cancer cells on experimental outcomes, we directly compared tumor-bearing (TB) mice inoculated with Lewis-lung carcinoma at 1x10 Results: While both TB groups showed lower weight gain and adiposity than vehicle controls, TB Discussion: The metabolic profile and hypothalamic gene expression can vary with differential initial tumor load, suggesting that the relationship between systemic energy balance and cancer progression is complex and not strictly linear. This finding should be carefully considered in the design and interpretation of future animal experiments and clinical studies.
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