ArticleRegenerative biomaterials2026
Coordination-based nanocomposite hydrogel promotes tissue regeneration under infection-compromised conditions.
Article in Regenerative biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Impaired tissue regeneration, rather than mere bacterial colonization, represents the core pathological challenge in infected wounds, where persistent infection, biofilm formation and inflammatory dysregulation collectively disrupt the healing process. Herein, we report a coordination-based nanocomposite hydrogel (DAP-Cu NGs) designed to restore regenerative capacity by integrating infection control with active microenvironmental remodeling. The system comprises daphnetin-copper nanoparticles (DAP-Cu NPs) self-assembled via coordination chemistry and loaded into a poloxamer thermosensitive hydrogel. This design achieves two key objectives: nanoconfinement of Cu
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