ArticleFrontiers in plant science2026
Integrated morphological, physiological, and transcriptomic analyses reveal the survival strategies of alpine
Article in Frontiers in plant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Alpine Methods: To elucidate the mechanisms underlying chronic heat tolerance, distinct from classical acute heat-shock responses, this study integrated phenotypic screening, physiological profiling, transcriptomics, and biochemical analysis of the glutathione system. Results: The heat-tolerant cultivar 'Gommer Waterer' maintained membrane integrity under 30-day chronic heat stress despite accumulating substantially elevated H₂O₂ levels, a dissociation consistent with preferential detoxification of lipid peroxidation products rather than broad-spectrum ROS scavenging. Comparative time-course transcriptomics revealed that the tolerant cultivar mounted a substantially larger and earlier transcriptional response than the heat-sensitive cultivar 'Fenjingling', with sustained enrichment of phenylpropanoid, lipid metabolism, and glutathione pathways. Weighted gene co-expression network analysis identified a key module significantly correlated with heat resilience traits and enriched in glutathione metabolism. Biochemical assays corroborated these network findings, with the tolerant cultivar showing higher constitutive GPX activity, a stress-induced surge in GST activity, and active glutathione redox cycling, whereas the sensitive cultivar displayed elevated GSH/GSSG ratios accompanied by transcriptional repression of recycling enzymes Discussion: Collectively, these findings suggest that glutathione-mediated detoxification of lipid peroxidation products is associated with membrane protection under prolonged thermal stress in this species, with the Theta-class hub gene
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