ArticleThe Journal of clinical and aesthetic dermatology2026
Plant Exosome Injection: A New Boost for Postlaser Vascular Repair.
Article in The Journal of clinical and aesthetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Screening of Metabolic Reprogramming-Related Diagnostic Biomarkers and Analysis of Immune Heterogeneity in Atopic Dermatitis Based on Multi-Cohort Validation.Clinical, cosmetic and investigational dermatology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicrovascular activation is a pivotal early event in oral wound healing, particularly in laser-induced injuries where thermal effects alter endothelial behavior. CD31, a key endothelial adhesion and signaling molecule, provides a reliable marker for evaluating angiogenic onset, vessel reorganization, and endothelial stability. Plant-derived nanovesicles (PDNVs) have emerged as promising biotherapeutics capable of modulating cellular communication, yet their influence on CD31-mediated vascular remodeling in laser wounds remains largely unexplored.
objectiveTo investigate how 2 distinct PDNV formulations modulate CD31 expression and CD31+ microvascular density in standardized blue diode laser wounds created in rabbit tongue tissue.
methodsControlled 450-nm diode laser micro-incisions were produced on rabbit tongues and treated locally with either Exoline or Glow exosomes. Untreated wounds served as controls. Tissue samples were harvested at baseline, Day 3, and Day 7. Histological evaluation focused primarily on CD31 immunohistochemistry to quantify endothelial activation, vessel budding, and remodeling intensity. Additional morphologic assessments supported interpretation of vascular changes.
resultsBoth PDNV formulations significantly increased CD31+ endothelial structures compared to controls. Exoline induced the highest early CD31 expression, accompanied by dense microvascular sprouting and pronounced endothelial clustering by Day 3. Glow produced a moderate but consistent elevation in CD31 labeling, with more gradual vessel organization. By Day 7, Exoline-treated wounds exhibited mature, well-oriented vessel networks, whereas Glow-treated tissues showed intermediate remodeling.
conclusionPDNVs effectively enhance CD31-mediated angiogenic activation following laser-induced mucosal injury, with Exoline demonstrating the most robust endothelial response. These findings highlight PDNVs as promising modulators of early microvascular remodeling in oral regenerative contexts.
Indexed as
Identifiers
42239844PMC13229155What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.