ArticleData in brief2026
Collagen I-to-III ratio data in healing rabbit Achilles tendon tissue treated with PDGF-BB: Comparison of dual Herovici staining with two single immunohistochemical labelings for Collagen I and Collagen III.
Article in Data in brief, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
After tendon rupture repair, the healing tendon tissue is characterized by an initial, immature deposition of collagen III, which is gradually replaced by mature collagen I. Due to common complications like re-rupture and peritendinous adhesions, a coaxially electrospun DegraPol tube releasing PDGF-BB was developed and tested in a rabbit Achilles tendon full-transection model after pulling it over the conventionally sutured tendon. Beyond cellularity and vascularization, the collagen I-to-III ratio serves as a key indicator of the healing progress. We provide comprehensive data on this ratio at three weeks post surgery, using two methods: Herovici (HV) dual-colour staining and immunohistochemical labelling (IHC) for collagen I and III. Ratios were calculated via colour histograms: red-to-blue for HV, and red-to-green for DAB stained IHC. Data are provided for five distinct anatomical zones: native tendon (NZ), similar-to-native (SZ), reactive zone/interface (RZ), hot zone/core (HZ), and intraspun zone within the fiber mesh pores (IS).
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