State-dependent reward circuit modulation gates social buffering of stress.

Urszula Skupio, Djemila Compaore, Jaehan Kwon, Nekhama Riznyk, Alexander Z Harris

Abstract readPreprint

In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Urszula SkupioDepartment of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA; Area Neuroscience, New York State Psychiatric Institute, New York, NY, USA.ORCID 0000-0003-3072-976X

Djemila CompaoreDepartment of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA; Area Neuroscience, New York State Psychiatric Institute, New York, NY, USA.

Jaehan KwonDepartment of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA; Area Neuroscience, New York State Psychiatric Institute, New York, NY, USA.ORCID 0009-0001-9688-9937

Nekhama RiznykDepartment of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA; Area Neuroscience, New York State Psychiatric Institute, New York, NY, USA.

Alexander Z HarrisDepartment of Psychiatry, Columbia University, College of Physicians and Surgeons, New York, NY, USA; Area Neuroscience, New York State Psychiatric Institute, New York, NY, USA.ORCID 0000-0001-9089-0366

Funding

VTA-NAc GABAergic communication underlying stress-induced reward deficitsR01MH124998 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI HARRIS, ALEXANDER · 2021 to 2025

$2.9M

NIMH NIH HHS R01 MH124998

6 · The paper itself

Abstract

Social experiences can profoundly shape emotional regulation and promote resilience to stress. Although the presence of companions is well-known to buffer the impact of stress in humans and rodents

Identifiers

PMID42239792

DOI10.21203/rs.3.rs-9441690/v1

PMCPMC13228811

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.