ArticleResearch square2026
Volume and Tempo: Cortical Excitability and Trial-to-Trial Consistency of Auditory Responses Distinguish Psychosis Biotypes.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
11 authors.
Funding
Abstract
ERPs average neural responses to stimuli across trials. This accentuates consistent activity over time but obscures differences in response strength and phase consistency from trial to trial. The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) identified three transdiagnostic psychosis Biotypes (BT1, BT2, BT3) that differ in cortical excitability and temporal coherence of neural responses. Single-trial power (STP) and inter-trial coherence (ITC) were measured across 3-55 Hz in auditory paired-stimuli and oddball tasks using a large multi-site cohort (n = 2 373). One-way ANOVAs over a continuous time-frequency epoch with FDR and cluster correction identified group differences, resulting in 15 significant STP and ITC features. Linear discriminant analysis of these features identified the dimensions that maximally separated Biotypes. The STP differences covered the entire trial epoch, showing the strongest alterations in the beta band (18-32 Hz), graded BT2 > > BT3 > HC > > BT1. The ITC differences were seen at specific time points primarily in low-frequency bands (3-17 Hz), graded HC > BT3 > BT1 > BT2. These dimensions were orthogonal and did not mirror ERP amplitudes across Biotypes. Biotypes were better distinguished by STP and ITC (Euclidean distances 0.9-2.2) than by DSM diagnosis (0.10-0.45). DSM groups alone did not benefit from this breakdown. Cortical excitability and phase precision are unique neurophysiological targets for the etiological investigation of psychosis Biotypes, which traditional ERP averaging obscures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.